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Results for "

Cholesterol absorption inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (7) Apoptosis (1) Autophagy (6) CETP (2) Cholinesterase (ChE) (1) Drug Intermediate (1) Drug Metabolite (3) Endogenous Metabolite (2) Isotope-Labeled Compounds (2) Keap1-Nrf2 (7) LDLR (1) Liposome (1) LXR (1) Microsomal Triglyceride Transfer Protein (MTP) (1) Monoamine Oxidase (1) Reference Standards (2) SARS-CoV (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (15) Infection (1) Inflammation/Immunology (2) Metabolic Disease (17) Neurological Disease (1)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17376

Ezetimibe Maximum Cited Publications 15 Publications Verification SCH 58235	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-104081

Cholestyramine 5+ Cited Publications Cholestyramine resin; Colestyramine	LDLR	Cardiovascular Disease Cancer
Cholestyramine (Colestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol.

HY-125854

Phosphatidylcholines, egg 2 Publications Verification	Liposome Cholinesterase (ChE) Monoamine Oxidase Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology
Phosphatidylcholines, egg are a type of phosphatidylcholine that can be isolated and extracted from eggs, primarily present in egg yolks. As a major phospholipid component of cell membranes, Phosphatidylcholines, egg play a key role in providing nutrition and protection to the body. Phosphatidylcholines, egg can inhibit oxidative stress and neurotoxicity, exerting neuroprotective effects. Additionally, Phosphatidylcholines, egg can suppress the lymphatic absorption of cholesterol in the intestine and are also used in research on intestinal lipid absorption .

HY-135391

Ezetimibe phenoxy glucuronide 2 Publications Verification Ezetimibe glucuronide; Ezetimibe β-D-glucuronide	Drug Metabolite	Metabolic Disease
Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .

HY-101722

Melinamide AC 223; DL-N-(α-Methylbenzyl)linoleamide	Acyltransferase	Metabolic Disease
Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of *cholesterol* absorption with an IC₅₀ of 20.9 μM.

HY-119220

Granotapide JTT-130	Microsomal Triglyceride Transfer Protein (MTP)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Granotapide is an orally active microsomal triglyceride transfer protein (MTP) inhibitor. Granotapide reduces the absorption of cholesterol and triglycerides by inhibiting MTP. Granotapide can be used in the research of coronary artery disease, obesity, diabetes mellitus and hypertension .

HY-136059

Desfluoro-ezetimibe	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable **cholesterol absorption** inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .

HY-17376S1

Ezetimibe-d4-1 SCH 58235-d₄-1	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17376R

Ezetimibe (Standard) Maximum Cited Publications 15 Publications Verification SCH 58235 (Standard)	Reference Standards Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe (Standard) is the analytical standard of Ezetimibe. This product is intended for research and analytical applications. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17376S

Ezetimibe-d4 SCH 58235-d₄	Autophagy Keap1-Nrf2 Isotope-Labeled Compounds	Cardiovascular Disease Cancer
Ezetimibe-d₄ (SCH 58235-d₄) is the deuterium labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-45131

Cholesterol absorption inhibitor 1	Drug Intermediate	Metabolic Disease
Cholesterol absorption inhibitor 1 (compound 21) is a **cholesterol absorption** inhibitor that reduces liver cholesteryl ester .

HY-129344

CL 277082	Acyltransferase	Metabolic Disease
CL 277082 is a potent and selective *acyl CoA:cholesterol* acyltransferase (ACAT)** inhibitor in microsomes. CL 277082 inhibits ACAT with IC₅₀ values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor .

HY-135391S

Ezetimibe phenoxy glucuronide-d4 Ezetimibe glucuronide-d₄; Ezetimibe β-D-glucuronide-d₄	Drug Metabolite	Metabolic Disease
Ezetimibe phenoxy glucuronide-d₄ is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .

HY-107176A

Hyzetimibe HS-25	Others	Metabolic Disease
Hyzetimibe is a cholesterol absorption inhibitor. Hyzetimibe blocks the intestinal absorption of cholesterol and phytol. Hyzetimibe is well tolerated in animal models, with an LD_max 2000 mg/kg in rats and an LD_max 500 mg/kg in rhesus monkeys .

HY-19251

CL-283796	Acyltransferase	Cardiovascular Disease Metabolic Disease
CL-283796 is a potent and orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. CL-283796 reduces low-density lipoprotein (LDL) cholesterol without affecting cholesterol absorption in African green monkeys. CL-283796 can be used for hypercholesterolemia research .

HY-135388

ent-Ezetimibe ent-SCH 58235	Drug Metabolite	Cardiovascular Disease
ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .

HY-106106

Tiqueside CP‐88,818; β‐Tigogenin cellobioside	CETP	Metabolic Disease
Tiqueside (CP‐88,818) is an orally active cholesterol absorption inhibitor. Tiqueside inhibits absorption of both dietary cholesterol and endogenous cholesterol excreted into the intestinal lumen via the bile. Tiqueside can be used in the research of hypercholesterolemia .

HY-19497

Canosimibe AVE-5530; BART-1741	CETP	Metabolic Disease
Canosimibe is a cholesterol absorption inhibitor extracted from patent WO2004087655A1.

HY-106902

F-1394	Acyltransferase	Cardiovascular Disease
F-1394 is an orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor that inhibits dietary cholesterol absorption in mice. F-1394 can be used in cardiovascular disease research .

HY-134451

Diethylumbelliferyl phosphate DEUP	Endogenous Metabolite	Metabolic Disease
Diethylumbelliferyl phosphate (DEUP), a selective and potent inhibitor of cholesterol esterase, does not inhibit protein kinase activity A in vitro, and it effectively disrupts steroidogenesis by blocking the transport of cholesterol into the mitochondria of steroidogenic cells, with an IC₅₀ of 11.6 μM, potentially limiting dietary cholesterol absorption.

HY-106938

Eldacimibe WAY-ACA 147	Acyltransferase	Cardiovascular Disease Metabolic Disease
Eldacimibe is an ACAT2 inhibitor. Eldacimibe can lower plasma cholesterol levels by blocking cholesterol absorption and can prevent macrophages from turning into foam cells. Eldacimibe can be used in the study of cardiovascular diseases (atherosclerosis), endocrine and metabolic diseases (hypercholesterolemia) .

HY-101722R

Melinamide (Standard) AC 223 (Standard); DL-N-(α-Methylbenzyl)linoleamide (Standard)	Acyltransferase Reference Standards	Metabolic Disease
Melinamide (Standard) is the analytical standard of Melinamide. This product is intended for research and analytical applications. Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.

HY-105086

Pamaqueside CP148623	SARS-CoV	Infection Metabolic Disease
Pamaqueside (CP148623) is a cholesterol absorption inhibitor and a potent binder of the SARS-CoV-2 receptor-binding domain (RBD), which may inhibit viral cellular entry. Pamaqueside can be utilized in metabolic and antiviral research .

HY-123666

Bay-02752 Bay o 2752	Acyltransferase	Cardiovascular Disease
Bay-02752 (Bay o 2752) is a lipid-lowering agent. Bay-02752 inhibits acyl-CoA activity in liver microsomes (IC₅₀ = 0.95 μg/mL). Bay-02752 inhibits intestinal cholesterol absorption in rats. Bay-02752 inhibits gallstone formation in hamsters .

HY-120984

Oleic Acid-2,6-diisopropylanilide	Endogenous Metabolite	Metabolic Disease
AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.1 Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC₅₀ of 7 nM.2 When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.

HY-17376S3

Ezetimibe-13C6 SCH 58235-¹³C₆	Isotope-Labeled Compounds Autophagy Keap1-Nrf2	Cancer
Ezetimibe- ¹³C₆ (SCH 58235- ¹³C₆) is the ¹³C-labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-W349716

LM-1554	Keap1-Nrf2	Cardiovascular Disease
LM-1554 is an orally active antihyperlipaemic agent. LM-1554 can inhibit cholesterol absorption in the gastrointestinal tract .

HY-182014

TLC-2716	LXR	Cardiovascular Disease Metabolic Disease
TLC-2716 is an orally available, gut- and liver-restricted inhibitor against LXRα and LXRβ, with EC₅₀ values of 7 nM and 15 nM, respectively. TLC-2716 represses LXRα/β transcriptional activity, downregulates genes involved in lipogenesis, lipid absorption and lipoprotein metabolism, and preserves peripheral reverse cholesterol transport. TLC-2716 reduces lipid accumulation, suppresses inflammation and fibrotic gene expression, enhances triglyceride-rich lipoprotein clearance, and improves glucose homeostasis and insulin sensitivity. TLC-2716 lowers serum and hepatic triglycerides, plasma cholesterol and other atherogenic lipid profiles in experimental models and humanized liver mice. TLC-2716 can be used for the research of dyslipidemia and related cardiometabolic disorders .

Cat. No.	Product Name	Target	Research Area

HY-P10342

Soystatin	Peptides	Cardiovascular Disease
Soystatin is a peptide extracted from soy protein, whose main activity is to inhibit the absorption of cholesterol. Soystatin, as a peptide with significant cholic acid binding ability, can be used in the study of cardiovascular diseases .

Cat. No.	Product Name	Chemical Structure

HY-17376S1

Ezetimibe-d4-1
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17376S

Ezetimibe-d4
Ezetimibe-d₄ (SCH 58235-d₄) is the deuterium labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-135391S

Ezetimibe phenoxy glucuronide-d4
Ezetimibe phenoxy glucuronide-d₄ is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .

HY-17376S3

Ezetimibe-13C6
Ezetimibe- ¹³C₆ (SCH 58235- ¹³C₆) is the ¹³C-labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

Cat. No.	Product Name		Classification

HY-125854

Phosphatidylcholines, egg 2 Publications Verification		Phospholipids
Phosphatidylcholines, egg are a type of phosphatidylcholine that can be isolated and extracted from eggs, primarily present in egg yolks. As a major phospholipid component of cell membranes, Phosphatidylcholines, egg play a key role in providing nutrition and protection to the body. Phosphatidylcholines, egg can inhibit oxidative stress and neurotoxicity, exerting neuroprotective effects. Additionally, Phosphatidylcholines, egg can suppress the lymphatic absorption of cholesterol in the intestine and are also used in research on intestinal lipid absorption .

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