897-83-6
Chemical Structure
Diethylumbelliferyl phosphate
Synonym(s): DEUP
- CAS No.: 897-83-6
- Formula:C14H17O6P
- Molecular Weight:312.25
IUPAC Name: diethyl (4-methyl-2-oxo-2H-chromen-7-yl) phosphate
InChIKey: GHGRYKAFUNNHBG-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C(C)=C1)C=CC(OP(OCC)(OCC)=O)=C2
Biological Activity: Diethylumbelliferyl phosphate (DEUP), a selective and potent inhibitor of cholesterol esterase, does not inhibit protein kinase activity A in vitro, and it effectively disrupts steroidogenesis by blocking the transport of cholesterol into the mitochondria of steroidogenic cells, with an IC50 of 11.6 μM, potentially limiting dietary cholesterol absorption.
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Diethylumbelliferyl phosphate | Diethylumbelliferyl phosphate (DEUP), a selective and potent inhibitor of cholesterol esterase, does not inhibit protein kinase activity A in vitro, and it effectively disrupts steroidogenesis by blocking the transport of cholesterol into the mitochondria of steroidogenic cells, with an IC50 of 11.6 μM, potentially limiting dietary cholesterol absorption. | |||||||||||||||||||||
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Keywords
