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DENV E protein

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By Targets:	Dengue Virus (8) Akt (1) Caspase (1) EGFR (1) Flavivirus (3) HIV (1) HSP (1) Ligands for Target Protein for PROTAC (2) PROTACs (1)
By Research Areas:	Cancer (1) Infection (9)

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Targets Recommended: Dengue Virus

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3942

Glabranine	Flavivirus Dengue Virus HIV	Infection
Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus . Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein .

HY-P990817

Anti-West Nile/dengue virus E protein Antibody (E60)	Dengue Virus Flavivirus	Infection
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection .

HY-P991764

Anti-Dengue virus type 4 E protein DIII Antibody (DV4-E88)	Dengue Virus	Infection
Anti-Dengue virus type 4 E protein DIII Antibody (DV4-E88) reacts with the DIII domain on the E protein of dengue virus serotype 4 (DENV-4). Anti-Dengue virus type 4 E protein DIII Antibody (DV4-E88) neutralizes 1036, TVP-376, and TVP-986 genotype II strains of DENV-4. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981) .

HY-P991769

Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96)	Dengue Virus	Infection
Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) reacts with sites along the lateral ridge of the DIII domain on the E protein of dengue virus serotype 2 (DENV-2). Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) against DENV-2 new Guinea C (NGC) infection in mice. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981) .

HY-161804

GNF-2-deg	PROTACs Dengue Virus	Infection
GNF-2-deg is a PROTAC degrader for dengue virus envelope protein (DENV E protein) with DC₅₀ of 0.83 μM. GNF-2-deg prevents viral entry by inhibiting E-mediated membrane fusion, prevents virion production by protein degradation, and thereby exhibits antiviral activity against DENV 2 with EC₉₀ of 3.5 μM. GNF-2-deg exhibits antiviral activity against ZIKV, JEV, WNV and YFV with EC₉₀ of 1.96-7.79 μM. (Pink: ligand for target protein (HY-161805); Black: linker (HY-42149); Blue: ligand for E3 ligase (HY-23095))

HY-176433

NSC-323241	Flavivirus	Infection
NSC-323241 is a potent *STT3A-mediated mega protein* complex assembly** inhibitor. NSC-323241 disrupts he endoplasmic reticulum (ER) mega complex nucleated by STT3A during dengue virus (DENV) and Zika virus (ZIKV) infection. NSC-323241 targets the binding of STT3A subcomplex with viral nonstructural proteins (e.g., NS2B, NS3) and host translocon proteins, disrupting the formation of viral replication microenvironment. NSC-323241 is promising for research of flavivirus infection, such as dengue fever and Zika virus .

HY-161807

DENV ligand 1	Dengue Virus Ligands for Target Protein for PROTAC	Infection
DENV ligand 1 is a ligand for DENV E protein. DENV ligand 1 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806) .

HY-161808

DENV ligand 2	Dengue Virus Ligands for Target Protein for PROTAC	Infection
DENV ligand 2 is the ligand for DENV E protein.DENV ligand 2 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806). DENV ligand 2 is the active form of DENV ligand 1 (HY-161807) .

HY-117252

HS-72	HSP EGFR Akt Dengue Virus Caspase	Infection Cancer
HS-72 is a selective allosteric inducible heat shock protein 70 Hsp70i inhibitor. HS-72 reduces ATP affinity of Hsp70i, elevates caspase 3/7 apoptotic activity, and promotes degradation of Hsp70 client proteins, including HER2 and Akt, and blocks DENV entry by disrupting Hsp70i association with the DENV receptor complex. HS-72 can be used for breast cancer and dengue virus infection research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990817

Anti-West Nile/dengue virus E protein Antibody (E60)	Dengue Virus Flavivirus	Infection
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection .

HY-P991764

Anti-Dengue virus type 4 E protein DIII Antibody (DV4-E88)	Dengue Virus	Infection
Anti-Dengue virus type 4 E protein DIII Antibody (DV4-E88) reacts with the DIII domain on the E protein of dengue virus serotype 4 (DENV-4). Anti-Dengue virus type 4 E protein DIII Antibody (DV4-E88) neutralizes 1036, TVP-376, and TVP-986 genotype II strains of DENV-4. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981) .

HY-P991769

Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96)	Dengue Virus	Infection
Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) reacts with sites along the lateral ridge of the DIII domain on the E protein of dengue virus serotype 2 (DENV-2). Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) against DENV-2 new Guinea C (NGC) infection in mice. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981) .

Glabranine	Infection Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Source Classification	Flavivirus Dengue Virus HIV
Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus . Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein .

Species:	Virus (10)
Tag:	His (10)
Source:	HEK293 (4) P. pastoris (2) Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74198

	E/Envelope Protein, Dengue virus 1 (101a.a, HEK293, His) E protein; DENV; DENV Envelope / DENV-E protein (His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 1 (101a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

HY-P704230

	DENV2 Envelope Protein (HEK293, His) Envelope protein/E protein (DENV); LGenome polyprotein; L	Virus	HEK293
	NS1 Protein, essential in virus budding, binds the cell membrane, forming a nucleocapsid that becomes the virus core. During entry, NS1 facilitates viral genome penetration post-hemifusion. NS1 migrates to the nucleus, influencing host functions, and counteracts host EXOC1's antiviral effects by sequestering and degrading EXOC1 via the proteasome pathway. Additionally, NS1 impedes RNA silencing by interfering with the host Dicer enzyme. DENV2 Envelope Protein (HEK293, His) is the recombinant DENV2 Envelope protein, expressed by HEK293, with N-His labeled tag.

HY-P74197

	E/Envelope Protein, Dengue virus 1 (101a.a, sf9, His) E protein; DENV; Envelope; Dengue virus (DENV) (type 1, strain US/Hawaii/1944) E/Envelope protein Domain III	Virus	Sf9 insect cells
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 1 (101a.a, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P74190

	E/Envelope Protein, Dengue virus 4 (395a.a, sf9, His) E protein; DENV; Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E / Envelope protein (ECD, His Tag)	Virus	Sf9 insect cells
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 4 (395a.a, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P74194

	E/Envelope Protein, Dengue virus 2 (429a.a, sf9, His) E protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope protein (ECD, His Tag)	Virus	Sf9 insect cells
	E/Envelope Protein, Dengue virus 2 (429a.a, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells, with C-His labeled tag.

HY-P74191

	E/Envelope Protein, Dengue virus 4 (101a.a, HEK293, His) E protein; DENV; Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E / Envelope protein (aa 579-679, His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 4 (101a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

HY-P74196

	E/Envelope Protein, Dengue virus 2 (102a.a, P.pastoris, His) E protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope protein (Domain III, His Tag)	Virus	P. pastoris
	E/Envelope Protein, Dengue virus 2 (102a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

HY-P74192

	E/Envelope Protein, Dengue virus 3 (429a.a, HEK293, His) E protein; DENV; Dengue virus (DENV)(type 3, strain Philippines/H87/1956) E / Envelope protein (aa 247-675, ECD, His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles. During entry, NS1 induces genome penetration into the host cytoplasm. E/Envelope Protein, Dengue virus 3 (429a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

HY-P74193

	E/Envelope Protein, Dengue virus 2 (103a.a, P.pastoris, His) E protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope protein (Domain III, His Tag)	Virus	P. pastoris
	E/Envelope Protein, Dengue virus 2 (103a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

HY-P74195

	E/Envelope Protein, Dengue virus 2 (399a.a, T356R, Q357E, W381R, L387R, sf9, His) E protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope protein (His Tag)	Virus	Sf9 insect cells
	E/Envelope Protein, Dengue virus 2 (399a.a, T356R, Q357E, W381R, L387R, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells, with C-His labeled tag.

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DENV E protein

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Natural
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