1 Result for "

Emirodatamab

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Emirodatamab" in MCE Product Catalog:

Cat. No.: HY-P99916
CAS No.: 2449199-61-3
Synonyms: AMG-427

Target:  

FLT3 CD3 TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Emirodatamab (AMG-427) is a bispecific T-cell engager (BiTE). Emirodatamab simultaneously binds FLT3 on the surface of acute myeloid leukemia (AML) cells and CD3 on the surface of T cells, thereby precisely recruiting immune effector cells to tumor sites. Emirodatamab potently induces T cell activation, secretion of proinflammatory cytokines (such as IFNγ, TNFα), and specific cytotoxicity, effectively lysing FLT3-positive tumor cells and inhibiting their growth. Emirodatamab not only significantly prolongs survival in mouse xenograft models and eliminates diseased cells in primates, but also exhibits a synergistic enhancement effect when combined with PD-1 blockade therapy. Emirodatamab is used in studies of acute myeloid leukemia, especially relapsed or refractory cases .
loading...
    loading...