1 Result for "

Entrectinib-d4

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Entrectinib-d4" in MCE Product Catalog:

Cat. No.: HY-12678S
Synonyms: NMS-E628-d4; RXDX-101-d4
Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice .