1 Result for "

Entrectinib-d8

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Entrectinib-d8" in MCE Product Catalog:

Cat. No.: HY-12678S1
CAS No.: 2251773-94-9
Purity:  99.82%
Synonyms: NMS-E628-d8; RXDX-101-d8
Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC50 values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .