1 Result for "

Ergolide

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Ergolide" in MCE Product Catalog:

3
Ergolide
Ergolide
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3 Cited Publications
Cat. No.: HY-N6893
CAS No.: 54999-07-4
Category:  

Phyllodium pulchellum (L.) Desv. Ketones, Aldehydes, Acids Plants Compositae Disease Research Fields Inflammation/Immunology Piptanthus nepalensis (Hook.) D. Don

Target:  

NF-κB NOD-like Receptor (NLR) Apoptosis Autophagy

Ergolide is an orally active dual inhibitor targeting NF-κB/p65 and NLRP3. Ergolide blocks the NF-κB signaling pathway and the nuclear translocation of p65, and irreversibly binds to the NACHT domain of NLRP3 to inhibit inflammasome assembly. Ergolide significantly reduces the production of inflammatory mediators (e.g., NO, PGE2) and cytokines, induces cancer cell apoptosis, autophagy and ROS generation. Ergolide also enhances the anti-tumor effect of vincristine. Ergolide alleviates acute lung injury via an NLRP3-dependent mechanism, and effectively improves the survival rate and behavioral function of septic mice and inflammatory zebrafish models. Ergolide is used in the research of metastatic uveal melanoma, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease), sepsis and acute lymphoblastic leukemia .
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