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Results for "

FSHRs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Estrogen Receptor/ERR (7) GnRH Receptor (1) MDM-2/p53 (1) Neuropeptide FF Receptor (1) PERK (1) Small Interfering RNA (siRNA) (3) TSH Receptor (1)
By Research Areas:	Cancer (1) Endocrinology (8) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12381

ML224 1 Publications Verification NCGC00242364; ANTAG3	TSH Receptor	Endocrinology
ML224 (NCGC00242364) is a selective TSHR antagonist with an IC₅₀ value of 2.1 µM. ML224 can be used in the study of Graves' disease and other thyroid disorders.

HY-150210

FSHR agonist 1	Estrogen Receptor/ERR	Endocrinology
FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC₅₀ of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR .

HY-P4190

Fsh receptor-binding inhibitor fragment(bi-10)	GnRH Receptor	Endocrinology
FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries .

HY-P3343A

hFSH-β-(33-53) TFA 1 Publications Verification	Estrogen Receptor/ERR	Cancer
hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a *FSHR* (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells .

HY-160857

TOP5668	Estrogen Receptor/ERR	Endocrinology
TOP5668 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5668 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats .

HY-164764

ADX61623	Estrogen Receptor/ERR	Endocrinology
ADX61623 is a potent follicle stimulating hormone (FSH) receptor (FSHR) negative allosteric modulator (NAM). ADX61623 shows luteinizing hormone receptor (LH-R) activity and is not active on thyroid-stimulating hormone (TSH) receptors. ADX61623 can be used for the study of estrogen dependent disease .

HY-160856

TOP5300 TOP05300	Estrogen Receptor/ERR	Endocrinology
TOP5300 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5300 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats .

HY-P10780

RFRP-3 (mouse) Neuropeptide NPVF (mouse)	Neuropeptide FF Receptor Apoptosis MDM-2/p53 PERK	Endocrinology
RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development .

HY-RS23431

Fshr Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fshr Rat Pre-designed siRNA Set A contains three designed siRNAs for Fshr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fshr Rat Pre-designed siRNA Set A Fshr Rat Pre-designed siRNA Set A

HY-RS05124

FSHR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FSHR Human Pre-designed siRNA Set A contains three designed siRNAs for FSHR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FSHR Human Pre-designed siRNA Set A FSHR Human Pre-designed siRNA Set A

HY-RS16988

Fshr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fshr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fshr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fshr Mouse Pre-designed siRNA Set A Fshr Mouse Pre-designed siRNA Set A

HY-182705

Org 214444-0	Estrogen Receptor/ERR	Endocrinology
Org 214444-0 is an orally active, nanomolar-potent and selective *FSHR* agonist, with EC₅₀ values of 2.0 nM and 1.2 nM in human and rat (measured in CHO cells). Org 214444-0 activates human granulosa cells in vitro, supports rat follicular development and induces ovulation in vivo. Org 214444-0 can be used for the research of infertility .

HY-W673613

ADX68692	Estrogen Receptor/ERR	Metabolic Disease
ADX68692 is an orally active negative allosteric modulators of follicle-stimulating hormone receptor with a log IC₅₀ of -5.71. ADX68692 can inhibit hCG-induced cAMP production and s ß-arrestin 2 recruitment in HEK293 cells. ADX68692 exhibits a partial effect in both mLTC-1 and primary rat Leydig cells. ADX68692 inhibits FSHR-promoted cAMP, progesterone and estradiol production. ADX68692 can reduce the number of oocytes recovered from the ampullae .

Cat. No.	Product Name	Target	Research Area

HY-P4190

Fsh receptor-binding inhibitor fragment(bi-10)	GnRH Receptor	Endocrinology
FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries .

HY-P3343A

hFSH-β-(33-53) TFA 1 Publications Verification	Estrogen Receptor/ERR	Cancer
hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a *FSHR* (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells .

HY-P10780

RFRP-3 (mouse) Neuropeptide NPVF (mouse)	Neuropeptide FF Receptor Apoptosis MDM-2/p53 PERK	Endocrinology
RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development .

Fshr Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Fshr Rat Pre-designed siRNA Set A contains three designed siRNAs for Fshr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

FSHR Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FSHR Human Pre-designed siRNA Set A contains three designed siRNAs for FSHR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fshr Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Fshr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fshr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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