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FuK

" in MedChemExpress (MCE) Product Catalog:

2

Inhibitors & Agonists

1

Peptides

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS04850
    FCSK Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FCSK Human Pre-designed siRNA Set A contains three designed siRNAs for FCSK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FCSK Human Pre-designed siRNA Set A
    FCSK Human Pre-designed siRNA Set A
  • HY-P11615
    FuK

    		Bacterial Infection
    FuK is a WK2-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an LD50 of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds .
    FuK

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