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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
GLIS2
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "GLIS2" in MCE Product Catalog:
Art. -Nr.: HY-RS05481
Target:
Forschungsgebiete:
GLIS2 Human Pre-designed siRNA Set A contains three designed siRNAs for GLIS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS21582
Target:
Forschungsgebiete:
Glis2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Glis2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS28100
Target:
Forschungsgebiete:
Glis2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Glis2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS05475
Target:
Forschungsgebiete:
GLI2 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS27255
Target:
Forschungsgebiete:
Gli2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gli2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-137567
CAS. Nr.: 210976-81-1
Target:
Forschungsgebiete:
Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth .
Art. -Nr.: HY-13901R
CAS. Nr.: 500579-04-4
Synonyms: NSC 136476 (Standard)
Target:
Forschungsgebiete:
GANT 61 (Standard) is the analytical standard of GANT 61. This product is intended for research and analytical applications. GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
Art. -Nr.: HY-12487
CAS. Nr.: 1788896-33-2
NL-103 is an inhibitor of histone deacetylases (HDACs) and Hedgehog, with the IC50 values of 21.3 nM, 57 nM, 74 nM, and 680 nM for HDAC1, HDAC2, HDAC3, and HDAC6, respectively. NL-103 can downregulate the expression of Gli2. NL-103 can be used in anti-cancer research .
Art. -Nr.: HY-RS20743
Target:
Forschungsgebiete:
Gli2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gli2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-183335
Anticancer agent 321 is a Smoothened (SMO) inhibitor with a human IC50 of 0.12 μM, enhanced aqueous solubility, good plasma and metabolic stability, moderate therapeutic index, preliminary safety profile, and moderate oral bioavailability in rats.Anticancer agent 321 binds to SMO’s 7-transmembrane helical channel, forming hydrogen bonds with Asp384 and hydrophobic/π-π interactions with His470, Phe391, Tyr394, stabilizing SMO’s inactive conformation to inhibit Hedgehog/GLI signaling.Anticancer agent 321 inhibits proliferation, suppresses colony formation, induces apoptosis, and downregulates Hedgehog/GLI pathway target genes GLI1, GLI2, Ptch1, HHip in cancer cells.Anticancer agent 321 inhibits tumor growth, downregulates Ki67 and SOX2, and upregulates cleaved-caspase 3 in tumor tissues.Anticancer agent 321 can be used for the research of cutaneous squamous cell carcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
