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Results for "

GS9219

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13640
    Rabacfosadine

    GS-9219; VDC-1101

    		 Nucleoside Antimetabolite/Analog Cancer
    Rabacfosadine (GS-9219), a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells.
    Rabacfosadine
  • HY-13640A
    Rabacfosadine succinate

    GS-9219 succinate; VDC-1101 succinate

    		 Nucleoside Antimetabolite/Analog Cancer
    Rabacfosadine (GS-9219) succinate, a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells .
    Rabacfosadine succinate
  • HY-101677
    cPrPMEDAP

    		Drug Metabolite Infection
    cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin .
    cPrPMEDAP
  • HY-185150
    PMEG

    9-(2-Phosphonylmethoxy)ethylguanine

    		 DNA/RNA Synthesis CMV Infection Inflammation/Immunology Cancer
    PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma [1][2].
    PMEG

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