2 Results for "

Gpx4-knockout

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Gpx4-knockout" in MCE Product Catalog:

33
33 Cited Publications
Cat. No.: HY-136057
CAS No.: 150651-39-1
Purity:  99.96%
Research Areas:  

Cancer

iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .
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Cat. No.: HY-126400
CAS No.: 1406-66-2
Purity:  98.6%
Tocopherols are orally effective antioxidants and ferroptosis inhibitors. Tocopherols scavenge ROS/RNS, alleviate DNA damage, downregulate cyclin D1/c-Myc/TFF/pS2/PGR in an ER-dependent manner, and inhibit ferroptosis mediated by lipid peroxidation. Tocopherols block the occurrence of ferroptosis in Gpx4-knockout Pfa1 cells, with an EC50 value of 1.0-2.3 μM. Tocopherols inhibit tumor growth. Tocopherols can be used in studies related to estrogen-mediated ER + breast cancer, oxidative stress-induced carcinogenesis, and ferroptosis regulation .
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