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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
Gram-positive bacterial biofilms
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "Gram-positive bacterial biofilms" in MCE Product Catalog:
Category:
other families Ketones, Aldehydes, Acids Plants Disease Research Fields Inflammation/Immunology
Target:
MA220607 is a FtsZ protein inhibitor with activity against both Gram-positive and Gram-negative bacteria. MA220607 inhibits bacterial growth and shows low bacterial resistance frequency. MA220607 increases bacterial membrane permeability and alters proton gradients. MA220607 blocks the formation of bacterial biofilms. MA220607 can be used in studies of bacterial infections .
Cat. No.: HY-P11165
CAS No.: 2173394-02-8
Cat. No.: HY-P5706
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Cat. No.: HY-175539
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DNA gyrase/Topo IV-IN-2 (Compound AK19) is an antibacterial agent with IC50 values of 0.783 μM and 7.136 μM against E. coli DNA gyrase and topoisomerase IV, respectively. DNA gyrase/Topo IV-IN-2 exhibits broad-spectrum antibacterial efficacy against both Gram-positive and Gram-negative pathogens. DNA gyrase/Topo IV-IN-2 can inhibit the biofilms of B. subtilis and MRSA, with an MIC of 1.9 μM against both B. subtilis and MRSA. DNA gyrase/Topo IV-IN-2 can be used in research related to anti-drug-resistant bacterial drugs .
Cat. No.: HY-178952
Anti-infective agent 12 (Compound A09) is a competitive inhibitor of type I signal peptidease (SPase I), with an IC50 of 4.475 μM and a Kd of 16.3 μM. Anti-infective agent 12 has the ability to disrupt bacterial membranes and remove biofilms. Anti-infective agent 12 exhibits potent bactericidal activity against Gram-positive bacteria, with MIC values of 4, 4, 8, and 8 μg/mL for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus suis, respectively. Anti-infective agent 12 remains effective against multi-drug resistant strains, but has weaker activity against Gram-negative bacteria (such as Escherichia coli and Salmonella), with MIC values > 64 μg/mL. Anti-infective agent 12 has low hemolytic activity and shows significant efficacy in mouse skin infection models .
Cat. No.: HY-P5709
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Cat. No.: HY-P11242
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Cat. No.: HY-184584
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Antibacterial agent 358 is an antibacterial agent. Antibacterial agent 358 selectively interacts with PG on bacterial cell membranes, causing membrane damage. Antibacterial agent 358 induces bacterial cell membrane depolarization, increased membrane permeability and leakage of intracellular components. Antibacterial agent 358 inhibits biofilm formation and disrupts established biofilms. Antibacterial agent 358 reduces bacterial load and alleviates tissue inflammation in a mouse skin abscess model. Antibacterial agent 358 can be used in research related to Gram-positive bacterial infections and skin abscesses .
Cat. No.: HY-183275
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Antibacterial agent 340 is a DNA gyrase inhibitor. Antibacterial agent 340 exhibits broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 340 disrupts bacterial cell membrane integrity, induces reactive oxygen species (ROS) accumulation, and inhibits and eradicates bacterial biofilms. Antibacterial agent 340 can be used for the research of bacterial infections .
Cat. No.: HY-P11897
Cat. No.: HY-187804
Antibacterial agent 368 is an antibacterial agent active against Gram-positive and Gram-negative strains. Antibacterial agent 368 exhibits moderate inhibitory activity against bacterial biofilm formation. The combination of Antibacterial agent 368 with Ampicillin (HY-B0522) shows synergistic effects against Staphylococcus aureus and Pseudomonas aeruginosa. Antibacterial agent 368 can be used in the research of bacterial infections .
Cat. No.: HY-182798
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Antibacterial agent 337 is an antibacterial agent. Antibacterial agent 337 specifically interacts with PG in bacterial cell membranes, triggering membrane disruption, membrane depolarization, increased permeability, cytoplasmic leakage, ROS accumulation and rapid bacterial death. Antibacterial agent 337 inhibits biofilm formation and disrupts mature biofilms. Antibacterial agent 337 exhibits potent in vivo antibacterial efficacy in a mouse model of Staphylococcus aureus skin abscess. Antibacterial agent 337 can be used in studies of Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus infections, vancomycin-resistant Enterococcus faecalis infections and bacterial biofilm infections .
Cat. No.: HY-144255
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Antibacterial agent 70 is an antibacterial agent that interacts with DNA, with a MIC value of 0.5 μg/mL against K. pneumonia and A. baumanii. Antibacterial agent 70 exhibits rapid bactericidal activity, low cytotoxicity to mammalian cells, and low tendency to induce drug resistance. Antibacterial agent 70 intercalates into DNA, disrupts bacterial membrane integrity, increases intracellular ROS production, reduces GSH activity, regulates membrane depolarization, enhances outer membrane permeability, and induces inner membrane damage. Antibacterial agent 70 can be used in studies related to multidrug-resistant bacterial infections and infections caused by drug-resistant Gram-negative pathogens .
Cat. No.: HY-P11894
Antimicrobial peptide 6b is a cationic macrocyclic antimicrobial peptide. It exhibits broad-spectrum antibacterial and antifungal activities, with a MIC of 1.5-6.2 μg/mL against drug-resistant Gram-positive bacteria, a MIC of 4-25 μg/mL against Gram-negative bacteria, and also shows activity against pathogenic fungi. It acts through a membrane disruption mechanism, has a unique "sandwich" conformation, low hemolytic activity, and can rapidly kill bacteria and eliminate bacterial and fungal biofilms. Antimicrobial peptide 6b can be used in studies of drug-resistant bacterial infections and fungal infections .
Cat. No.: HY-183751
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Antibacterial agent 346 is a broad-spectrum Antibacterial agent and BsFtsZ inhibitor, with an IC50 of 69.67 μg/mL against BsFtsZ. Antibacterial agent 346 selectively binds to phosphatidylglycerol, disrupts membrane integrity, increases permeability, triggers depolarization and causes intracellular protein leakage. Antibacterial agent 346 induces intracellular ROS accumulation, which in turn triggers oxidative stress and cell death. Antibacterial agent 346 eradicates mature biofilms formed by Gram-positive and Gram-negative bacteria. Antibacterial agent 346 exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii. Antibacterial agent 346 can be used in the research of bacterial infections .
Cat. No.: HY-P11898
Cat. No.: HY-182315
Antibacterial agent 334 is an antimicrobial peptide with in vitro activity against both Gram-negative and Gram-positive bacteria. Antibacterial agent 334 disrupts bacterial membrane integrity, induces membrane depolarization, impairs bacterial physiological processes without causing immediate bacterial lysis, and reduces the formation of Staphylococcus aureus biofilms. Antibacterial agent 334 can be used in studies related to Staphylococcus aureus infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
