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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

HEK293 reporter cells

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-102028
    KY1220
    3 Publications Verification

    		 Wnt β-catenin Cancer
    KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway, with an IC50 of 2.1 μM in HEK293 reporter cells .
    KY1220
  • HY-168532
    ST2-IN-1

    		Interleukin Related Inflammation/Immunology
    ST2-IN-1 is a ST2 inhibitor. ST2-IN-1 blocks the binding interaction between ST2 and IL-33, thereby attenuating the downstream ST2/IL-33 signaling pathway. ST2-IN-1 reduces IL-1β release from mast cells and alleviates ST2 upregulation in cells. ST2-IN-1 can be used for research on inflammatory and immune-related diseases .
    ST2-IN-1
  • HY-178037
    TLR9 antagonist 1

    		Toll-like Receptor (TLR) Interleukin Related TNF Receptor Inflammation/Immunology
    TLR9 antagonist 1 is a selective hTLR9 antagonist with an IC50 of 0.1 nM against hTLR9. TLR9 antagonist 1 exhibits favorable pharmacokinetic and pharmacodynamic properties. TLR9 antagonist 1 can be used in the research of systemic lupus erythematosus .
    TLR9 antagonist 1
  • HY-174370
    MePT-S-N-Pme

    		SARS-CoV Infection
    MePT-S-N-Pme is an inhibitor of SARS-CoV-2 RdRp activity. MePT-S-N-Pme demonstrates a significant reduced reporter activity with an IC50 of 7 μM in HEK 293 cells. MePT-S-N-Pme has a slight inhibitory effect on nucleotidyltransferase activity. MePT-S-N-Pme significantly inhibits SARS-CoV-2 replication in vitro .
    MePT-S-N-Pme
  • HY-102028R
    KY1220 (Standard)

    		Reference Standards Wnt β-catenin Cancer
    KY1220 (Standard) is the analytical standard of KY1220 (HY-102028). This product is intended for research and analytical applications. KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway, with an IC50 of 2.1 μM in HEK293 reporter cells .
    KY1220 (Standard)
  • HY-168384
    M04

    		STING TNF Receptor Interleukin Related CD28 Inflammation/Immunology
    M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases .
    M04
  • HY-N17600
    Pterocenoid C

    		NF-κB Others
    Pterocenoid C is an inhibitor of the NF-κB pathway and can be used for research on diseases related to the NF-κB pathway .
    Pterocenoid C
  • HY-181894
    XYQ3-B11

    		PPAR Cardiovascular Disease Metabolic Disease
    XYQ3-B11 is a potent PPARα agonist with an EC50 of 8.33 μM. XYQ3-B11 activates PPARα. XYQ3-B11 can be used for the research of dyslipidemia .
    XYQ3-B11
  • HY-185652
    dTAG-TRIMTAC

    		PROTACs E1/E2/E3 Enzyme Neurological Disease Inflammation/Immunology
    dTAG-TRIMTAC is a PROTAC-like degrader targeting TRIM21. dTAG-TRIMTAC forms a ternary complex with TRIM21 and target proteins to drive degradation of oligomeric/assembled substrates via TRIM21 clustering-based activation, with degradation dependent on endogenous TRIM21. dTAG-TRIMTAC can be used for the research of neurodegenerative disease and inflammatory disease .
    dTAG-TRIMTAC
  • HY-124640
    SMN2 modulator-1

    		DNA/RNA Synthesis Neurological Disease
    SMN2 modulator-1 is a brain-penetrant survival motor neuron (SMN) modulator. SMN2 modulator-1 post-translationally stabilizes SMN protein and increases SMN protein levels independent of SMN2 transcription. SMN2 modulator-1 can be used for the research of spinal muscular atrophy[1].
    SMN2 modulator-1

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