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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
HGD
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "HGD" in MCE Product Catalog:
Cat. No.: HY-RS06151
Target:
Research Areas:
HGD Human Pre-designed siRNA Set A contains three designed siRNAs for HGD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-103641AS1
CAS No.: 2748638-78-8
Synonyms: (2R)-Octyl-2-HG-d17
Cat. No.: HY-RS17679
Target:
Research Areas:
Hgd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hgd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24140
Target:
Research Areas:
Hgd Rat Pre-designed siRNA Set A contains three designed siRNAs for Hgd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-108046
CAS No.: 869743-37-3
Synonyms: UP302
Target:
Tyrosinase PI3K Akt Bcl-2 Family Caspase PINK1/Parkin Atg8/LC3 Mitophagy Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor. Nivitol competitively and reversibly inhibits tyrosinase, suppressing melanin production. Nivitol inhibits homogentisate 1,2-dioxygenase (HGD). In human leukemia cells, Nivitol inhibits PI3K/AKT pathway phosphorylation, increases ROS, decreases mitochondrial membrane potential, and induces G2/M cell cycle arrest, apoptosis, and PINK1/Parkin-mediated mitophagy. Nivitol exhibits inhibition of tumor growth in the MV411 xenograft mouse model. Nivitol is used for research on exogenous ochronosis, hyperpigmentation, and leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
