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HIV-1 capsid protein

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標的別:	HIV (9) Reference Standards (1) Virus Protease (2)
研究分野別:	Infection (11)

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Targets Recommended: HIV Integrase HIV HIV Protease

製品番号	製品名	Target	研究分野	構造式

Lenacapavir Maximum Cited Publications 19 Publications Verification GS-6207	HIV	Infection
Lenacapavir (GS-6207) is an **HIV-1 capsid** inhibitor. Lenacapavir binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .

PF-3450074 5 Publications Verification PF-74	HIV	Infection
PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC₅₀=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.

Bevirimat 2 Publications Verification PA-457; MPC-4326; YK FH312	Virus Protease	Infection
Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of *HIV-1* viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies .

Lenacapavir sodium Maximum Cited Publications 19 Publications Verification GS-6207 sodium	HIV	Infection
Lenacapavir (GS-6207) sodium is an **HIV-1 capsid** inhibitor. Lenacapavir sodium binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir sodium exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir sodium is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .

Dezecapavir VH-499; VH4011499	HIV	Infection
Dezecapavir (VH-499) is a *HIV-1* capsid protein inhibitor. Dezecapavir exhibits picomolar-level antiviral activity against a variety of *HIV-1* laboratory strains and clinical isolates in vitro. Dezecapavir inhibits the early and late stages of the *HIV-1* life cycle, blocking nuclear import, reverse transcript production, virion assembly, maturation, and post-nuclear import/pre-integration replication processes. Dezecapavir can be used in studies related to *HIV-1* infection .

HIV Capsid-IN-2	HIV	Infection
HIV Capsid-IN-2 (Compound IC-2b4) is a potent **HIV-1 capsid protein** (CA) inhibitor. HIV Capsid-IN-2 shows inhibitory effects against both *HIV-1* (EC₅₀=0.08 μM) and *HIV-2. HIV* Capsid-IN-2 exerts inhibitory effects during both early and late stages of infection by directly and stably binding to HIV-1 CA .

HIV-1 inhibitor-12	HIV	Infection
HIV-1 inhibitor-12 is potent *HIV-1* inhibitor. HIV-1 inhibitor-12 inhibits HIV-1 capsid protein polymerization with an IC₅₀ of 9 nM (WO2021104413A1, compound 1-1a) .

PF-46396	HIV	Infection
PF-46396 is a potent *HIV-1* inhibitor with an EC₅₀ value of 0.206 µM. PF-46396 shows antiviral activity. PF-46396 inhibits the processing of capsid (CA)/spacer peptide 1 (SP1) (p25) Gag precursor proteins and blocks maturation of the viral core particle .

HIV capsid modulator 2	HIV	Infection
HIV capsid modulator 2 (Compound 7t) is a modulator for the HIV capsid (CA) protein. HIV capsid modulator 2 exhibits antiviral activity, which inhibits HIV-1 IIIB strain and HIV-2 ROD strain with EC₅₀ of 0.04 and 0.13 μM. HIV capsid modulator 2 is metabolically stable in human liver microsomes .

Bevirimat (Standard) PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)	Reference Standards Virus Protease	Infection
Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].

Niruriside	HIV	Infection
Niruriside is a HIV REV/RRE complex inhibitor. Niruriside specifically inhibits the binding interaction between HIV REV protein and RRE RNA, with an IC₅₀ of 3.3 μM, and shows no significant activity against the unrelated R17 capsid protein/operator RNA binding system. At the tested concentrations, Niruriside fails to protect CEM-SS cells from acute HIV-1 infection. Niruriside can be used in the research of human immunodeficiency virus (HIV) infection .

製品番号	製品名	Category	Target	構造式

Bevirimat 2 Publications Verification PA-457; MPC-4326; YK FH312	Infection Triterpenes Classification of Application Fields Terpenoids Myrtaceae Plants Syzygium aromaticum Disease Research Fields Source Classification	Virus Protease
Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of *HIV-1* viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies .

Bevirimat (Standard) PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)	Triterpenes Structural Classification Terpenoids Myrtaceae Plants Syzygium aromaticum Source Classification	Reference Standards Virus Protease
Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].

Species:	Virus (6)
Tag:	His (6)
Source:	HEK293 (1) E. coli (5)

製品番号	Compare	製品名	Species	Source	Image

	p24 Protein, HIV-1 (AAB50258, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (AAB50258, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag.

	p24 Protein, HIV-1 (AAA44868, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (AAA44868, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag.

	p24 Protein, HIV-1 (BAH97658, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (BAH97658, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag.

	p24 Protein, HIV-1 (ACI05538, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (ACI05538, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag.

	p24 Protein, HIV-1 (AAB61122, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (AAB61122, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag.

	p24 Protein, HIV-1 (AAB50258, HEK293, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	HEK293
	p24 Protein, HIV-1 (AAB50258, HEK293, His) is the recombinant virus-derived p24 protein, expressed by HEK293, with C-His tag.

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