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Cat. No.: HY-111964S1

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Lenacapavir-d₅

(Synonyms: GS-6207-d₅)

Lenacapavir-d₅ (GS-6207-d₅) is the deuterium labeled Lenacapavir (HY-111964). Lenacapavir (GS-6207) is an HIV-1 capsid inhibitor. Lenacapavir binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection.

For research use only. We do not sell to patients.

Formula: C₃₉H₂₇D₅ClF₁₀N₇O₅S₂
Molecular Weight:973.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lenacapavir-d₅ Chemical Structure

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All HIV Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 2189684-44-2
Molecular Weight 973.31
Formula C₃₉H₂₇D₅ClF₁₀N₇O₅S₂
SMILES

O=C(N[C@H](C1=NC(C#CC(S(=O)(C([2H])([2H])[2H])=O)(C)C)=CC=C1C2=CC=C(Cl)C3=C2N(CC(F)(F)F)N=C3NS(=O)(C)=O)CC4=CC(F)=CC(F)=C4)C([2H])(N5N=C(C(F)(F)F)C6=C5C(F)(F)[C@@]7([H])[C@]6([H])C7)[2H]
Synonyms

GS-6207-d₅
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.