10 Results for "

HeLa (KB)

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "HeLa (KB)" in MCE Product Catalog:

Inotodiol
Inotodiol
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Cat. No.: HY-120149
CAS No.: 35963-37-2
Purity:  98.29%
Category:  

Microorganisms Tetracyclic Triterpenoids Terpenoids Disease Research Fields Cancer

Target:  

Toll-like Receptor (TLR) MDM-2/p53 MMP Caspase SOD p38 MAPK NF-κB Apoptosis

Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active .
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6-Methoxyflavone
6-Methoxyflavone
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Cat. No.: HY-W097625
CAS No.: 26964-24-9
Category:  

Flavonoids Flavones Thymelaeaceae Plants Pimelea simplex F.Muell.

Target:  

Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO)

6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway in HeLa cells. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases .
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Amorfrutin A
Amorfrutin A
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Cat. No.: HY-130073
CAS No.: 80489-90-3
Category:  

Leguminosae Simple Phenylpropanols Amorpha fruticosaL. Phenylpropanoids Plants

Target:  

NF-κB Apoptosis

Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis .
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Rubipodanone A
Rubipodanone A
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Cat. No.: HY-N7980
CAS No.: 2170211-22-8
Category:  

Quinones Rubia podantha Rubiaceae Plants Disease Research Fields Naphthalene Quinones Cancer

Target:  

NF-κB

Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .
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CE-2072
CE-2072
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Cat. No.: HY-119337
CAS No.: 208840-22-6
Target:  

Ser/Thr Protease

Research Areas:  

Infection

CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease .
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Diperamycin
Diperamycin
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Cat. No.: HY-N14163
CAS No.: 220766-06-3
Category:  

Microorganisms Macrolide Antibiotics Antibiotics

Target:  

Bacterial

Diperamycin has activity against Gram-positive bacteria, including Enterococcus seriolicida and MRSA (MICs of 0.10-0.20 μg/mL). Diperamycin also strongly inhibits the activity of L1210, P388, LS-180, KB, HeLaS3, Meth A and B16-BL6 (IC50s of 0.009-0.098 μg/mL) .
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Isotenulin
Isotenulin
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Cat. No.: HY-N15297
CAS No.: 10092-04-3
Category:  

Terpenoids Sesquiterpenes Plants Compositae Helenium arizonicum S.F.Blake

Target:  

P-glycoprotein

Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142) .
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Ossamycin
Ossamycin
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Cat. No.: HY-N14853
CAS No.: 2057463-74-6
Category:  

Microorganisms Macrolide Antibiotics Antibiotics

Target:  

Bacterial Fungal

Ossamycin is a macrolide antibiotic. Ossamycin has anti-fungal effect, and it has weaker anti-Gram-positive bacterial effect. Ossamycin inhibits L cells, Epstein-Barr ascites cancer cells, KB cells, sarcoma-180 cells, L-1210 cells, HeLa cells in cell culture with IC50s (μg/mL) of 0.007, 0.008, 0.005, 0.008, 0.003, 0.005, respectively .
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Tylophoridicine F
Tylophoridicine F
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Cat. No.: HY-N17419
CAS No.: 790234-59-2
Category:  

Apocynaceae Alkaloids Other Alkaloids Plants Tylophora ovata (Lindl.) Hook. ex Steud.

Target:  

Others

Tylophoridicine F is a cytotoxic agent. Tylophoridicine F can be isolated from T. atrofolliculata. Tylophoridicine F exhibits more cytotoxic activity on cells compared to Adriamycin (assessed using ileocecal adenocarcinoma cells and keratin-forming tumor cells) .
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6-Methoxyflavone (Standard)
6-Methoxyflavone (Standard)
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Cat. No.: HY-W097625R
CAS No.: 26964-24-9
Category:  

Flavonoids Flavones Thymelaeaceae Plants Pimelea simplex F.Muell.

Target:  

Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO) Reference Standards PERK

6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625). This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases .
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