Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Hh-signaling pathway
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Hh-signaling pathway" in MCE Product Catalog:
24
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
3
Ciliobrevin A (HPI-4) is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM .
2
2 Cited Publications
Cat. No.: HY-N0247
CAS No.: 58558-08-0
Category:
Plants Umbelliferae Disease Research Fields Saccharides Cancer Carphephorus corymbosus (Nutt.) Torr. & A.Gray Monosaccharides
Target:
Cat. No.: HY-17514S
CAS No.: 1217510-38-7
Synonyms: R51211-d5
Cat. No.: HY-17514S1
CAS No.: 1217512-35-0
Synonyms: R51211-d3
Cat. No.: HY-17514R
CAS No.: 84625-61-6
Synonyms: R51211 (Standard)
Category:
Research Areas:
SANT 2 is a potent Hh-signaling pathway antagonist. SANT 2 interferes with the expression of Gli1. SANT 2 causes developmental delay in medaka embryos. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers .
Cat. No.: HY-17514S2
CAS No.: 1309272-50-1
Synonyms: R51211-d9
Cat. No.: HY-13654
CAS No.: 878204-96-7
IPI-269609 is an orally effective Smoothed (SMO) inhibitor that targets the Hedgehog (Hh) signaling pathway. IPI-269609 specifically reduces the ALDH-bright (high aldehyde dehydrogenase activity) cell subset, which is considered the "cancer stem cells" in pancreatic cancer. IPI-269609 significantly inhibits the migration and colony formation of pancreatic cancer cells. IPI-269609 effectively inhibits pancreatic cancer metastasis in a mouse model. IPI-269609 can be used for pancreatic cancer research .
SMO-IN-2 is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity .
Cat. No.: HY-18287A
CAS No.: 1359944-60-7
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease .
Cat. No.: HY-150567
CAS No.: 2376914-71-3
SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity .
Cat. No.: HY-W414581
CAS No.: 240129-30-0
Synonyms: 3ß,27-Dihydroxy-5-cholesten-7-one
Cat. No.: HY-N0247R
CAS No.: 58558-08-0
Category:
Plants Umbelliferae Saccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Monosaccharides
Target:
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
