1 Result for "

IGN523

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "IGN523" in MCE Product Catalog:

Art. -Nr.: HY-P991669
Synonyms: AML-01

Target:  

Caspase Apoptosis

Forschungsgebiete:  

Cancer

IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM). IGN523 induces antibody-dependent cell-mediated cytotoxicity (ADCC) activity, lysosomal membrane permeabilization, and inhibition of essential amino acid transport, ultimately leading to caspase-3 and caspase-7-mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in multiple tumor xenograft models. IGN523 is useful in the research of non-small cell lung cancer (NSCLC), acute myeloid leukemia (AML), and other cancers. .
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