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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
IL-2 inducible T cell kinase
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "IL-2 inducible T cell kinase" in MCE Product Catalog:
Cat. No.: HY-149917
PROTAC ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice), with good plasma exposure levels. PROTAC ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo .
Cat. No.: HY-141864
CAS No.: 2655557-54-1
Target:
Research Areas:
ITK/TRKA-IN-1 is a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA) with an IC50 value of 1.0 nM and 96 % inhibition, respectively.
Cat. No.: HY-167759
CAS No.: 2143097-05-4
Synonyms: Pomalidomide-PEG2-CH2COOH
Research Areas:
Pomalidomide-PEG2-acetic acid (Pomalidomide-PEG2-CH2COOH) is a conjugate of CRBN ligand Pomalidomide (HY-10984) and a linker. Pomalidomide-PEG2-acetic acid can be used for PROTAC synthesis .
Cat. No.: HY-P705930
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ITK; T-cell-Specific kinase; IL2 inducible T cell kinase; kinase EMT; EMT; Homolog Of Mouse T-cell Itk/Tsk; LYK; IL2-inducible T-cell kinase; PSCTK2; IL2 inducible T-cell kinase; Interleukin-2-inducible T-cell kinase; Tyrosine-Protein kinase LYK; Tyrosine
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P74795
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ITK; T-cell-Specific kinase; IL2 inducible T cell kinase; kinase EMT; EMT; Homolog Of Mouse T-cell Itk/Tsk; LYK; IL2-inducible T-cell kinase; PSCTK2; IL2 inducible T-cell kinase; Interleukin-2-inducible T-cell kinase; Tyrosine-Protein kinase LYK; Tyrosine-Protein kinase ITK/TSK; Tyrosine-Protein kinase Lyk; IL-2-inducible T-cell kinase; LPFS1
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-189477
CAS No.: 1557236-81-3
Target:
Research Areas:
GNE-7056 is an orally active interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.2 nM against human kinase, and exhibits high selectivity over LCK kinase. GNE-7056 inhibits PLCγ-1 phosphorylation, suppresses the production of IL-2, IL-4, IL-13 and TH2 cytokines, reduces CD4 + T-cell proliferation, and inhibits activation-induced cell death of CD4 + T cells by decreasing the abundance of FasL. GNE-7056 can be used in asthma-related research .
Cat. No.: HY-110113
CAS No.: 1265822-30-7
CTA056 is an ITK (IL-2-inducible T-cell kinase) inhibitor with an IC50 of 0.1 μM. CTA056 selectively targets malignant T cells and modulates oncomirs. CTA056 induces apoptosis and is a potential therapeutic agent for the research of T-cell leukemia and lymphoma .
Cat. No.: HY-183539
CAS No.: 3111036-70-2
Target:
Research Areas:
INCB191358 is a selective and orally active inhibitor of diacylglycerol kinase α/ζ/ι (DGKα/ζ/ι ) with IC50 values of 0.12, 0.36 and 0.36 nM. INCB191358 induces antigen-dependent T-cell activation, induces IL-2 production and enhances antitumor efficacy in combination with PD-1 blockade. INCB191358 can be used for the research of cancer, such as colon carcinoma .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
