1 Result for "

Inotodiol

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Inotodiol" in MCE Product Catalog:

Inotodiol
Inotodiol
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Cat. No.: HY-120149
CAS No.: 35963-37-2
Purity:  98.29%
Category:  

Microorganisms Tetracyclic Triterpenoids Terpenoids Disease Research Fields Cancer

Target:  

Toll-like Receptor (TLR) MDM-2/p53 MMP Caspase SOD p38 MAPK NF-κB Apoptosis

Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active .
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