1 Result for "

JCS 1

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "JCS 1" in MCE Product Catalog:

Cat. No.: HY-164977
CAS No.: 3093519-24-2
Target:  

PROTACs Phosphatase

연구분야:  

Cancer

JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC50 in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders .
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