1 Result for "

Jervine (Standard)

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Jervine (Standard)" in MCE Product Catalog:

Jervine (Standard)
Jervine (Standard)
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Cat. No.: HY-N0836R
CAS No.: 469-59-0
Synonyms: 11-Ketocyclopamine (Standard)
Category:  

Alkaloids Piperidine Alkaloids Veratrum nigrum Linn. Plants Liliaceae Extract

Target:  

Reference Standards Hedgehog Wnt Akt mTOR AMPK DNA/RNA Synthesis Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism

Jervine (Standard) (11-Ketocyclopamine (Standard)) is the analytical standard of Jervine (HY-N0836). This product is intended for research and analytical applications. Jervine (11-Ketocyclopamine) is an orally active steroidal alkaloid and Hedgehog signaling pathway inhibitor. Jervine can be isolated from Veratrum californicum. Jervine regulates Wnt, inhibits the AKT/mTOR signaling pathway, and activates the AMPK signaling pathway. Jervine induces DNA damage, Apoptosis, Autophagy, ROS production and Mitochondrial damage. Jervine exhibits anti-cancer and anti-inflammatory activities. Jervine reduces tumor growth rate and weight in xenograft models. Jervine can be used in studies related to triple-negative breast cancer, nasopharyngeal carcinoma and non-small cell lung cancer .
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