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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
KDM2B
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "KDM2B" in MCE Product Catalog:
3
3 Cited Publications
Domaines de recherche:
TFMB-(R)-2-HG is a cell membrane-permeable (R)-2-HG and acute myeloid leukemia (AML) oncogenic factor. TFMB-(R)-2-HG competitively inhibits α-ketoglutarate-dependent dioxygenases such as KDM2B and FTO. TFMB-(R)-2-HG impairs cell differentiation in response to Estrogen withdrawal. TFMB-(R)-2-HG is used in acute myeloid leukemia and glioma research [2] .
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KDM2B-IN-1 (Example 20) is an effective inhibitor of histone demethylase (KDM2B), with an IC50 value of 0.021 μM. KDM2B-IN-1 can be used in proliferative diseases, such as cancer research .
Target:
Domaines de recherche:
KDM2B-IN-4 (Compound 182b) is a histone demethylase KDM2B inhibitor with an IC50 of 1.12 nM. KDM2B-IN-4 can be used for the research of hyperproliferative diseases such as cancers .
Target:
Domaines de recherche:
KDM2B-IN-1 (example 32) is a histone demethylase (kdm2b) inhibitor with an IC50 of 0.016 nM. KDM2B-IN-1 can be used for hyperproliferative diseases research .
Domaines de recherche:
U7D-1 is a USP7 PROTAC degrader that induces selective proteasomal degradation of USP7. U7D-1 destabilizes and downregulates the expression of variant PRC1 complex subunits PCGF1, RING1A and PCGF6, and also slightly reduces the protein level of KDM2B. U7D-1 decreases cell viability, arrests neuroblastoma cells at the G0/G1 cell cycle phase, and downregulates the expression of target genes of PAX3::FOXO1 in FP-RMS cells. U7D-1 increases the level of cleaved PARP in FP-RMS cells, induces cell apoptosis (apoptosis), and upregulates the expression of muscle differentiation markers MYH1 and MYF5. U7D-1 inhibits the growth and proliferation of p53 wild-type and mutant cancer cells, and regulates the apoptosis pathway and E2F pathway. U7D-1 is applicable to studies on neuroblastoma, fusion-positive rhabdomyosarcoma, p53-mutant cancers and cancer-related research [2] .
Cat. No.: HY-RS07210
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Domaines de recherche:
KDM2B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-139600
CAS No.: 1966933-87-8
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Domaines de recherche:
KDM2B-IN-3 is a histone demethylase KDM2B inhibitor extracted from patent WO2016112284A1, compound 183c. KDM2B-IN-3 can be used for the research of cancer .
Cat. No.: HY-RS16813
Target:
Domaines de recherche:
Kdm2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23253
Target:
Domaines de recherche:
Kdm2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702918
Pureté: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CXXC2; FBL10; FBXL10; JHDM1B; NDY1; PCCX2; KDM2B
Species:
Source:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
