1 Result for "

LB101

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "LB101" in MCE Product Catalog:

Art. -Nr.: HY-P991004
CAS. Nr.: 2923687-56-1
Synonyms: LB-101

Target:  

CD47 PD-1/PD-L1

Forschungsgebiete:  

Cancer

Itanistomig (LB-101) is a tetravalent bispecific antibody targeting PD-L1 and CD47. Itanistomig blocks PD-L1 and achieves tumor enrichment through binding to PD-L1, and also exerts conditional CD47 blocking activity via cleavage of the hinge linker in the PD-L1-positive tumor microenvironment. Itanistomig induces antibody-dependent cellular phagocytosis in human CD14 + cells and drives tumor regression. Itanistomig can be used in research related to solid tumors .
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