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LGF308

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-181756
    LGF308

    		PROTACs Epigenetic Reader Domain Cancer
    LGF308 is a PROTAC degrader of BRD4 that exhibits selective cytotoxicity toward cancer cells over normal cells. LGF308 mediates the formation of a ternary complex between BRD4 and DCAF11 to achieve BRD4 degradation. LGF308 induces tumor cell apoptosis by upregulating apoptosis-related proteins. LGF308 inhibits tumor cell proliferation and migration in breast cancer and triple-negative breast cancer cell lines. LGF308 can be used for the research of breast cancer .
    LGF308
  • HY-181757
    DCAF11 ligand-Linker Conjugate 1

    		E3 Ligase Ligand-Linker Conjugates Apoptosis Cancer
    DCAF11 ligand-Linker Conjugate 1 is a conjugate of a DCAF11 ligand and a linker. DCAF11 ligand-Linker Conjugate 1 can be used for the synthesis of PROTAC LGF308 (HY-181756) .
    DCAF11 ligand-Linker Conjugate 1
  • HY-W288798
    DCAF11 ligand 2

    		Ligands for E3 Ligase Cancer
    DCAF11 ligand 2 is an E3 ligase ligand that can be used in the recruitment of DCAF11. DCAF11 ligand 2 can be connected to the BRD4 ligand (HY-78695) by a linker to synthesis of PROTAC BRD4 degrader LGF308 (HY-181756) .
    DCAF11 ligand 2

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