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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
Losartan Carboxaldehyde (Standard)
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "Losartan Carboxaldehyde (Standard)" in MCE Product Catalog:
Cat. No.: HY-114950R
CAS No.: 114798-36-6
Synonyms: Losartan Carboxaldehyde (Standard); DuP 167 (Standard)
EXP3179 (Standard) (Losartan Carboxaldehyde (Standard)) is the analytical standard of EXP3179 (HY-114950). This product is intended for research and analytical applications. EXP3179 is a metabolite of Losartan (HY-17512). EXP3179 binds to AT1R with an affinity of 20 nM and blocks ANGII-induced AT1R signaling, inhibiting ERK1/2 activation. EXP3179 reduces NADPH oxidase activity. EXP3179 inhibits Phenylephrine (HY-B0769)-induced aortic contraction through an endothelium-dependent, NO-dependent mechanism. EXP3179 dose-dependently inhibits type I collagen-induced platelet aggregation and activation through GPVI binding, reducing platelet adhesion to the injured site. EXP3179 lowers blood pressure in normotensive and spontaneously hypertensive rats and mice. EXP3179 can be used for research on type 2 diabetes, hypertensive heart disease, hypertension, thrombosis, and coronary artery disease .
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