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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
MAO-B active site
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "MAO-B active site" in MCE Product Catalog:
Cat. No.: HY-181141
Research Areas:
AChE/MAO-B-IN-8 is an acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) inhibitor with IC50 values of 0.72 and 0.19 μM. AChE/MAO-B-IN-8 interactions with AChE and MAO-B active-site amino acid residues. AChE/MAO-B-IN-8 can be used for the research of Alzheimer’s disease .
Cat. No.: HY-187811
Research Areas:
MAO-B-IN-62 is a MAO-B inhibitor with an IC50 of 0.8 μM against MAO-B. MAO-B-IN-62 also acts as a PPARγ agonist with an EC50 of 14.6 μM. MAO-B-IN-62 binds to the active site of free MAO-B and activates PPARγ, both with a slow dissociation rate and sustained target-binding capacity. MAO-B-IN-62 exhibits antioxidant and anti-inflammatory activities. MAO-B-IN-62 can be used in the research of neurodegenerative diseases .
Cat. No.: HY-181937
CAS No.: 3022330-81-7
Research Areas:
Multi-target kinase-IN-10 (Compound 6l) is an orally active, blood-brain barrier-permeable, selective, reversible, and competitive MAO-B inhibitor with an IC50 of 0.0053 μM. Multi-target kinase-IN-10 competes with substrates for binding to the active site of MAO-B, chelates Cu 2+ ions, inhibits Cu 2+-induced ROS production, and reduces the release of NO, TNF-α, and IL-1β. Multi-target kinase-IN-10 ameliorates Parkinson's disease .
Cat. No.: HY-181268
CAS No.: 3069131-62-7
Target:
Research Areas:
MAO-B-IN-53 is a human monoamine oxidase B (hMAO-B) inhibitor with an IC50 of 0.066 μM. MAO-B-IN-53 exhibits mixed reversible inhibition, binds stably to the hMAO-B active site, and shows high selectivity over hMAO-A. MAO-B-IN-53 acts as a neuroprotective agent, protects against 6-OHDA-induced damage, and exhibits low neurotoxicity in neuroblastoma cells. MAO-B-IN-53 can be used for the research of Parkinson's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
