35 Results for "

MAPK8

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "MAPK8" in MCE Product Catalog:

4
4 Cited Publications
Referencia número: HY-N2593
No. CAS: 32507-66-7
Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .
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4
4 Cited Publications
Referencia número: HY-P80728
Synonyms: AI849689 antibody; c Jun N terminal kinase 1 antibody; C-JUN kinase 1 antibody; c-Jun N-terminal kinase 1 antibody; EC 2.7.11.24 antibody; JNK 1 antibody; JNK antibody; JNK-46 antibody; JNK1A2 antibody; JNK21B1/2 antibody; MAP kinase 8 antibody; MAPK 8 antibody; MAPK8 antibody; Mitogen activated protein kinase 8 antibody; MK08_HUMAN antibody; p54 gamma antibody; Prkm8 antibody; Protein kinase JNK1 antibody; Protein kinase, mitogen-activated, 8 antibody; SAPK 1 antibody; SAPK gamma antibody; SAPK1 antibody; Stress-activated protein kinase 1 antibody

Host:  

Rabbit

Application:  

WB, IP

Reactivity:  

Human, Mouse, Rat, Hamster

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2
2 Cited Publications
Referencia número: HY-P80830
Synonyms: JNK 46; JNK 55; MAPK10; MAPK9; MAPK8; SAPK1b; SAPK1; SAPK; PRKM10; PRKM9; PRKM8

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, FC

Reactivity:  

Human, Mouse, Rat

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1
1 Cited Publications
Referencia número: HY-P73848
Pureza:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Terminal Kinase; SAPK1C; MAP Kinase 8; Mitogen-Activated Protein Kinase 8; SAPK1c
Species:  
Human
Source:  
Sf9 insect cells
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Referencia número: HY-148061
No. CAS: 2769753-53-7
Pureza:  99.28%
DB1113 is a multi-kinase PROTAC degrader. DB1113 induces the ubiquitination and degradation of ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used to study diseases or disorders mediated by aberrant kinase activity .
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Referencia número: HY-RS08121
Áreas de investigación:  

Others

MAPK8 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPK8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-148063
No. CAS: 2769753-47-9
Pureza:  98.80%
DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity .
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Referencia número: HY-RS08123
Áreas de investigación:  

Others

Mapk8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mapk8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-RS08122
Áreas de investigación:  

Others

Mapk8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mapk8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-RS08124
Áreas de investigación:  

Others

MAPK8IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPK8IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-RS08125
Áreas de investigación:  

Others

MAPK8IP2 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPK8IP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-RS08126
Áreas de investigación:  

Others

MAPK8IP3 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPK8IP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-RS28583
Áreas de investigación:  

Others

Mapk8ip1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mapk8ip1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Referencia número: HY-N2593R
No. CAS: 32507-66-7
Isorhapontigenin (Standard) is the analytical standard of Isorhapontigenin (HY-N2593). This product is intended for research and analytical applications. Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes.
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Referencia número: HY-P705421
Pureza:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:  
Mouse
Source:  
Sf9 insect cells
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Referencia número: HY-N20729
No. CAS: 99633-12-2
Eucommin A is a natural polyphenolic antioxidant. Eucommin A forms stable complexes with EGFR and MAPK8 via hydrogen bonding and hydrophobic interactions, and regulates osteoarthritis-related Autophagy. Eucommin A is applicable to research related to oxidative stress, such as osteoarthritis .
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Referencia número: HY-P86251
Synonyms: MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; MAPK9; JNK2; PRKM9; SAPK1A; Mi

Host:  

Rabbit

Application:  

WB, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

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Referencia número: HY-P705577
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:  
Human
Source:  
E. coli
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Referencia número: HY-P705996
Pureza:  ≥ 90%, as determined by reducing SDS-PAGE .
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:  
Human
Source:  
Sf9 insect cells
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Referencia número: HY-P703020
Pureza:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:  
Mouse
Source:  
E. coli
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