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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
MARK2
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "MARK2" in MCE Product Catalog:
3
3 Cited Publications
PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability .
Target:
研究分野:
MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively . MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells [2]. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .
Target:
PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1 SnRK
研究分野:
RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC. RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].
製品番号: HY-RS08150
Target:
研究分野:
MARK2 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS24069
Target:
研究分野:
Mark2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mark2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS17609
Target:
研究分野:
Mark2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mark2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-120877A
純度: 98.70%
Target:
研究分野:
(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 [2] .
製品番号: HY-P82359
別名: ELKL motif kinase 1 antibody;
ELKL motif kinase antibody;
EMK-1 antibody;
EMK1 antibody;
MAP/microtubule affinity regulating kinase 2 antibody;
MAP/microtubule affinity-regulating kinase 2 antibody;
MARK2 antibody;
MARK2_HUMAN antibody;
MGC99619 antibody;
PAR 1 antibody;
Par 1b antibody;
PAR1 homolog antibody;
Par1b antibody;
Ser/Thr protein kinase PAR 1B antibody;
Serine/threonine protein kinase EMK antibody;
Serine/threonine protein kinase MARK2 antibody;
Serine/threonine-protein kinase MARK2 antibody;
製品番号: HY-182743
CAS 番号: 2803349-61-1
OICR19451 is an orally active dual NUAK1/NUAK2 and MARK2/MARK3 kinase inhibitor, with IC50 values of 12 nM and 10 nM against NUAK1 and NUAK2, and 101 nM and 124 nM against MARK2 and MARK3, respectively. OICR19451 modulates the Hippo signaling pathway, increases the phosphorylation level of YAP, enhances the cytoplasmic localization of YAP/TAZ, and inhibits the expression of oncogenes. OICR19451 inhibits cancer cell growth, reduces metastasis, promotes tumor capsule formation, and improves mouse survival in an orthotopic breast cancer model. OICR19451 can be used for research related to triple-negative breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
