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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
MK3
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "MK3" in MCE Product Catalog:
5
5 Cited Publications
Target:
Research Areas:
MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo .
5
5 Cited Publications
Target:
Research Areas:
MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 8.5 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2 .
2
2 Cited Publications
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PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect .
Cat. No.: HY-107427R
CAS No.: 1276121-88-0
Research Areas:
PF-3644022 (Standard) is the analytical standard of PF-3644022 (HY-107427). This product is intended for research and analytical applications. PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated Kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect .
Cat. No.: HY-RS08134
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Research Areas:
MAPKAPK3 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPKAPK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P74763
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAP kinase-activated protein kinase 3; MAPKAPK-3; MK-3; Chromosome 3p kinase
Species:
Source:
Cat. No.: HY-RS22584
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Kcna3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kcna3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07099
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KCNA3 Human Pre-designed siRNA Set A contains three designed siRNAs for KCNA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702663
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3; MAP kinase-activated protein kinase 3; 3pK; 3PK; MAPKAP3; MAPKAP kinase 3; chromosome 3p kinase; MAPK-activated protein kinase 3; MK-3; MAPKAP-K3; MAPKAPK-3
Species:
Source:
Cat. No.: HY-P83325A
Synonyms: MAPKAPK3; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3; Chromosome 3p kinase; 3pK
Cat. No.: HY-RS18320
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Mapkapk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mapkapk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24798
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Research Areas:
Mapkapk3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mapkapk3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
