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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
MS154
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "MS154" in MCE Product Catalog:
MS154 is a first-in-class E3 ligase cereblon-recruited EGFR degrader with Kd values of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutant, respectively. MS154 potently induces degradation of mutant, but not wild-type, EGFR in cancer cell lines in an E3 ligase-dependent manner. MS154 exhibits anticancer effects against lung cancer (blue: E3 ligase ligand (HY-103596); black: linker (HY-W096167); pink: EGFR ligand (HY-168305)) .
Cat. No.: HY-168305
CAS No.: 2550394-08-4
Research Areas:
EGFR ligand-11 is a target protein ligand for EGFR and can be used to synthesize PROTAC MS154 (HY-141640) .
Cat. No.: HY-168306
Target:
Research Areas:
8-Iodooctan-1-amine is a PROTAC linker that can be used in the synthesis of PROTAC MS154N (HY-157579) .
Cat. No.: HY-168307
CAS No.: 2550393-20-7
Research Areas:
Me-Thalidomide-O-C8-NH2 is an E3 ligase ligand-linker conjugate. Me-Thalidomide-O-C8-NH2 can be used in the synthesis of MS154N (HY-157579) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
