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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Methylenetetrahydrofolate reductase
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Methylenetetrahydrofolate reductase" in MCE Product Catalog:
23
23 Publications Verification
Research Areas:
DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile .
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6 Cited Publications
Synonyms: L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid
Category:
Human Gut Microbiota Metabolites Microorganisms Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-14520S
CAS No.: 1356841-72-9
Cat. No.: HY-14520S1
Synonyms: L-5,6,7,8-Tetrahydrofolic acid-13C5; L-Tetrahydrofolic acid-13C5
Target:
Research Areas:
Arfolitixorin calcium is a bioactive compound that acts as an enzyme substrate. Arfolitixorin calcium is used as a substrate for methylenetetrahydrofolate reductase to generate 5-methyltetrahydrofolate. Arfolitixorin calcium may have potential applications in neurobiological research, particularly in studies related to gene expression and metabolism. Research on arfolitixorin calcium helps reveal the functional genetics of bird genes .
Cat. No.: HY-109051
CAS No.: 31690-11-6
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite
Target:
Cat. No.: HY-16638
CAS No.: 76849-19-9
Synonyms: PDDF
Target:
Research Areas:
CB 3717 is a potent inhibitor of human thymidylate synthetase, competitively binding with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). It also competitively inhibits human dihydrofolate reductase with dihydrofolate (Ki = 2.3 X 10(-8) M). In WI-L2 human lymphoblastoid cells, CB 3717 treatment led to a significant decrease in cellular dTTP levels and a notable increase in dUMP levels, indicating a disruption in nucleotide metabolism. The growth-inhibitory effect of CB 3717 was reversed by thymidine supplementation, demonstrating that thymidylate synthetase became rate-limiting in the presence of this compound. Delayed thymidine supplementation beyond 8 hours resulted in severe cytotoxicity, underscoring the critical timing of nucleotide rescue strategies in CB 3717-treated cells .
Cat. No.: HY-14520B
CAS No.: 150731-85-4
Synonyms: L-5,6,7,8-Tetrahydrofolic acid trihydrochloride; L-Tetrahydrofolic acid trihydrochloride
Target:
Research Areas:
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) trihydrochloride is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid trihydrochloride is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid trihydrochloride serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
Cat. No.: HY-118251
CAS No.: 123685-36-9
Research Areas:
PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.
Cat. No.: HY-109051C
CAS No.: 149930-93-8
Target:
Cat. No.: HY-W766751
Synonyms: 5,10-Methylenetetrafolate-d4; ANX-510 free acid-d4
Synonyms: L-5,6,7,8-Tetrahydrofolic acid (Standard); L-Tetrahydrofolic acid (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
