1356841-72-9
Chemical Structure
Tetrahydrofolic acid-d4
- CAS No.: 1356841-72-9
- Formula:C19H19D4N7O6
- Molecular Weight:449.45
IUPAC Name: (4-(((2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl-6,7-d2)methyl-d2)amino)benzoyl)-L-glutamic acid
InChIKey: MSTNYGQPCMXVAQ-KLSHAWTBSA-N
SMILES: O=C1C2=C(NC(N)=N1)NC([2H])C(N2)([2H])C([2H])([2H])NC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O
Biological Activity: Tetrahydrofolic acid-d4 is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1][2].
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Tetrahydrofolic acid-d4 | Tetrahydrofolic acid-d4 is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid. | |||||||||||||||||||||
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Tetrahydrofolic acid-13C5 | Tetrahydrofolic acid-13C5 (L-5,6,7,8-Tetrahydrofolic acid-13C5) is 13C labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid. | |||||||||||||||||||||
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Tetrahydrofolic acid | 96.77% | Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Clara B García-Calderón, et al. Genotoxicity of Tetrahydrofolic Acid to Hematopoietic Stem and Progenitor Cells. Cell Death Differ. 2018 Nov;25(11):1967-1979. [Content Brief]
