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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
NADase
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "NADase" in MCE Product Catalog:
Target:
Research Areas:
NADase is an ectoenzyme/membrane-bound enzyme targeting nicotinamide adenine dinucleotide (NAD +). NADase regulates intracellular NAD + homeostasis by hydrolyzing NAD + into nicotinamide mononucleotide (NMN) and ADP-ribose. NADase is promising for research of autoimmune diseases (e.g., systemic sclerosis, systemic lupus erythematosus) and aging-related disorders .
10
Target:
Research Areas:
DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD +-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection .
Cat. No.: HY-134358A
Purity: 99.81%
Target:
Research Areas:
Ara-F-NAD+ sodium is an arabino analogue of NAD +. Ara-F-NAD+ sodium is a potent, reversible and slow-binding CD38 NADase inhibitor .
Cat. No.: HY-134358
CAS No.: 133575-27-6
Target:
Research Areas:
Ara-F-NAD+ is an arabino analogue of NAD +. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor .
Cat. No.: HY-182500A
CAS No.: 3020765-70-9
Target:
Research Areas:
(S,S)-SARM1-IN-9 (Compound MY-13A) is a stereoselective SARM1 inhibitor with covalent binding properties. (S,S)-SARM1-IN-9 covalently modifies Cys311 in the autoregulatory ARM domain of wild-type SARM1, thereby blocking NADase activity, without inhibiting the SARM1 C311A or SARM1 C311S mutants. (S,S)-SARM1-IN-9 blocks vacor- and vincristine-induced axon degeneration in primary rodent dorsal root ganglion neurons. (S,S)-SARM1-IN-9 can be used for research on axon degeneration-dependent neurological disorders, including chemotherapy-induced peripheral neuropathy .
Cat. No.: HY-P702882
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SARM1; Sterile Alpha And Armadillo Repeat Protein; Sterile Alpha And TIR Motif Containing 1; SAM Domain-Containing Protein 2; SAMD2; Tir-1 Homolog; SARM; NADase SARM1; Sterile Alpha And TIR Motif-Containing Protein 1; MyD88-5; NADP(+) Hydrolase SARM1; HSA
Species:
Human
Source:
HEK293
Cat. No.: HY-P705957
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SARM1; Sterile Alpha And Armadillo Repeat Protein; Sterile Alpha And TIR Motif Containing 1; SAM Domain-Containing Protein 2; SAMD2; Tir-1 Homolog; SARM; NADase SARM1; Sterile Alpha And TIR Motif-Containing Protein 1; MyD88-5; NADP(+) Hydrolase SARM1; HSA
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
