2 Results for "

NHC-TP

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "NHC-TP" in MCE Product Catalog:

Art. -Nr.: HY-145668
CAS. Nr.: 90597-20-9
Reinheit:  ≥99.0%
Forschungsgebiete:  

Infection Cancer

Cyclopentenyl uracil is a non-cytotoxic Uridine-Cytidine Kinase inhibitor and an antagonist of EIDD-1931 (NHC) (HY-125033) bioactivation. Cyclopentenyl uracil blocks NHC phosphorylation by inhibiting UCK1/UCK2, reduces intracellular NHC-TP accumulation, and depletes UTP/CTP pools, thereby antagonizing the antiviral activity of NHC and inhibiting dengue virus replication. Cyclopentenyl uracil is used in research on SARS-CoV-2 infection, dengue virus infection, leukemia, and solid tumors .
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Art. -Nr.: HY-135867
CAS. Nr.: 34973-27-8
NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .
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