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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
PC12 nerve cells
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "PC12 nerve cells" in MCE Product Catalog:
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2
2 Cited Publications
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PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75 NTR. PD 90780 inhibits NGF-p75 NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12 nnr5 cells, respectively .
Cat. No.: HY-P0131A
CAS No.: 2828432-44-4
Synonyms: Laminin (925-933) TFA
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Cat. No.: HY-117517
CAS No.: 141731-76-2
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Cat. No.: HY-W250121
CAS No.: 9000-65-1
Cat. No.: HY-P10998
CAS No.: 270919-17-0
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Cat. No.: HY-P0131
CAS No.: 110590-60-8
Synonyms: Laminin (925-933)
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Cat. No.: HY-165616
CAS No.: 309711-72-6
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NS 1231 is a neurotrophic-like compound with neuroprotective effect. NS 1231 can rescue nerve growth factor (NGF)-differentiated PC12 cells from death induced by withdrawal of trophic factors. NS 1231 can stimulate NGF-induced neurite outgrowth of undifferentiated PC12 cells. NS 1231 can be used for the research of neurological disease, such as stroke .
Cat. No.: HY-N3938
CAS No.: 110414-77-2
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Cat. No.: HY-11055
CAS No.: 393856-87-6
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KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective .
Cat. No.: HY-N3928
CAS No.: 173294-74-1
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Cat. No.: HY-133968R
CAS No.: 474-63-5
Synonyms: Ostreasterol (Standard)
Cat. No.: HY-133968S1
Synonyms: Ostreasterol-13C
Cat. No.: HY-183384
CAS No.: 143723-64-2
5'-Cholesteryl phosphoramidite is an antisense oligonucleotide conjugate targeting the p75 nerve growth factor receptor. 5'-Cholesteryl phosphoramidite downregulates the mRNA and protein levels of p75. 5'-Cholesteryl phosphoramidite enhances the cellular uptake efficiency of conjugated phosphorothioate oligonucleotides in differentiated PC12 cells .
Cat. No.: HY-175841
CAS No.: 3075165-36-2
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Tau Protein Phosphorylation-IN-1 is a tau protein phosphorylation inhibitor that potently protects PC12 cells against Aβ25–35-induced cytotoxicity (EC50 = 1.93 μM), and can penetrate the blood-brain barrier (BBB).Tau Protein Phosphorylation-IN-1 reverses the hyperphosphorylation of tau, significantly inhibits the expression of certain immune-related cytotoxic factors, suppresses the MAPK and NF-κB signaling pathways, and significantly inhibits the expression of RAGE and the apoptosis factors Bax/Bcl-2, both in vitro and in vivo. Tau Protein Phosphorylation-IN-1 relieves nerve damage, and improves learning and memory in an Alzheimer’s disease (AD) mouse model. Tau Protein Phosphorylation-IN-1 can be used for AD research .
Cat. No.: HY-N18211
CAS No.: 1613615-07-8
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Cat. No.: HY-N12170
CAS No.: 903559-03-5
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Cat. No.: HY-110166R
CAS No.: 77422-99-2
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PD 90780 (Standard) is the analytical standard of PD 90780 (HY-110166). This product is intended for research and analytical applications. PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively .
Cat. No.: HY-124152
CAS No.: 173043-84-0
Synonyms: Methyl-3,4-dephostatin
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3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of MAP kinase .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
