77422-99-2
77422-99-2
Chemical Structure
PD 90780
- CAS No.: 77422-99-2
- Formula:C19H14N4O4
- Molecular Weight:362.34
IUPAC Name: 7-benzamido-4-methyl-9-oxo-4,9-dihydropyrazolo[5,1-b]quinazoline-2-carboxylic acid
InChIKey: IAZAGXDMMVWYKF-UHFFFAOYSA-N
SMILES: CN1C2=CC(C(O)=O)=NN2C(C3=CC(NC(C4=CC=CC=C4)=O)=CC=C13)=O
Biological Activity: PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively[1] .
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PD 90780 | 98.83% | PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively . | ||||||||||||||||||||
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PD 90780 (Standard) | ≥98% | PD 90780 (Standard) is the analytical standard of PD 90780 (HY-110166). This product is intended for research and analytical applications. PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively . | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.52
HY-180869PDE11A modulator-1 -
Similarity Score 0.50
HY-148179Neuropeptide Y5 receptor ligand-1 -
Similarity Score 0.50
HY-101088CeMMEC13 -
Similarity Score 0.49
HY-149317ZINC475239213 -
Similarity Score 0.49
HY-111097AF3442 -
Similarity Score 0.49
HY-124643RIPK2-IN-3 -
Similarity Score 0.49
HY-112355Aurora kinase inhibitor-2 -
Similarity Score 0.49
HY-138102SSAA09E3 -
Similarity Score 0.48
HY-15647BRD9539 -
Explore the MedChemAI to find more analogs
References
- [1]. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11. [Content Brief]
