143723-64-2
143723-64-2
Chemical Structure
5'-Cholesteryl phosphoramidite
- CAS No.: 143723-64-2
- Formula:C43H76N3O4P
- Molecular Weight:730.06
InChIKey: LLDRAIRYAJXEEP-CRQKJHHESA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(NCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C
Biological Activity: 5'-Cholesteryl phosphoramidite is an antisense oligonucleotide conjugate targeting the p75 nerve growth factor receptor. 5'-Cholesteryl phosphoramidite downregulates the mRNA and protein levels of p75. 5'-Cholesteryl phosphoramidite enhances the cellular uptake efficiency of conjugated phosphorothioate oligonucleotides in differentiated PC12 cells[1].
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5'-Cholesteryl phosphoramidite | 5'-Cholesteryl phosphoramidite is an antisense oligonucleotide conjugate targeting the p75 nerve growth factor receptor. 5'-Cholesteryl phosphoramidite downregulates the mRNA and protein levels of p75. 5'-Cholesteryl phosphoramidite enhances the cellular uptake efficiency of conjugated phosphorothioate oligonucleotides in differentiated PC12 cells. | |||||||||||||||||||||
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