5'-Cholesteryl phosphoramidite
5'-Cholesteryl phosphoramidite is an antisense oligonucleotide conjugate targeting the p75 nerve growth factor receptor. 5'-Cholesteryl phosphoramidite downregulates the mRNA and protein levels of p75. 5'-Cholesteryl phosphoramidite enhances the cellular uptake efficiency of conjugated phosphorothioate oligonucleotides in differentiated PC12 cells.
For research use only. We do not sell to patients.
- CAS No.: 143723-64-2
- Formula: C43H76N3O4P
- Molecular Weight:730.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
5'-Cholesteryl phosphoramidite (5 μM) conjugated to the 5'-end of a p75-targeted phosphorothioate oligonucleotide enhances cellular uptake and p75 mRNA downregulation in differentiated PC12 cells, but only induces minor p75 protein downregulation, and requires a concentration of 5 μM for efficacy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 143723-64-2
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Molecular Weight 730.06
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Formula C43H76N3O4P
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SMILES
C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(NCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5'-Cholesteryl phosphoramidite Related Classifications
HY-183384 Related Classifications
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