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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
PD-L1 dimer interface
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "PD-L1 dimer interface" in MCE Product Catalog:
Cat. No.: HY-182047
CAS No.: 2983098-90-2
Target:
Research Areas:
PD-1/PD-L1-IN-61 is a PD-1/PD-L1 interaction inhibitor with a human IC50 of 5.3 nM. PD-1/PD-L1-IN-61 embeds into the hydrophobic pocket at the PD-L1 dimer interface, stabilizing binding through hydrogen bonds and π-π stacking with PD-L1 residues. PD-1/PD-L1-IN-61 acts as an immune activator, enhances immune-killing activity of peripheral blood mononuclear cells against cancer cells, restores T-cell immune function, and promotes IFN-γ secretion. PD-1/PD-L1-IN-61 can be used for the research of triple-negative breast cancer .
Cat. No.: HY-184295
Target:
Research Areas:
PD-1/PD-L1-IN-66 is a PD-1/PD-L1 immune checkpoint inhibitor with an IC50 of 3 nM for blocking the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-66 shows good affinity for PD-L1 dimers with a Kd value of 0.75 nM. PD-1/PD-L1-IN-66 can reactivate the proliferation of cytotoxic T cells. PD-L1 ligand-2 is applicable for cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
