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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
PROTAC BRD4 Degrader-23
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "PROTAC BRD4 Degrader-23" in MCE Product Catalog:
Cat. No.: HY-161093
Target:
Research Areas:
PROTAC BRD4 Degrader-23 is a visible light-regulated BRD4 PROTAC degrader, with DC50 values of 6871 nM and < 30 nM in the dark and under light exposure, respectively; its IC50 values are 1172 nM and 140 nM under the corresponding conditions. PROTAC BRD4 Degrader-23 shows inhibited activity in dark environments, and recovers BRD4 degradation ability upon irradiation with 405 nm visible light. PROTAC BRD4 Degrader-23 inhibits tumor cell proliferation in a visible light-dependent manner. PROTAC BRD4 Degrader-23 can be used in studies of BRD4-dependent B-cell lymphoma .
Cat. No.: HY-175797
Target:
Research Areas:
E3 ligase Ligand 82 is an E3 ligase VHL ligand. E3 ligase Ligand 82 can be coupled with BRD4 ligand JQ-1 carboxylic acid (HY-78695) via the linker Hydroxy-PEG3-CH2-Boc (HY-141209) to form PROTAC BRD4 Degrader-23 (HY-161093) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
