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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
PROTAC HER2 degrader-1
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "PROTAC HER2 degrader-1" in MCE Product Catalog:
Cat. No.: HY-177008
CAS No.: 2897640-93-4
PROTAC HER2 degrader-1 is a selective HER2 PROTAC degrader with a DC50 of 69 nM. PROTAC HER2 degrader-1 induces ubiquitination and degradation of HER2 via the ubiquitin-proteasome system, thereby inhibiting the downstream PI3K/AKT/mTOR and RAS/RAF/MEK/ERK signaling pathways. PROTAC HER2 degrader-1 inhibits the proliferation of HER2-positive cancer cells, induces apoptosis and arrests the cell cycle. PROTAC HER2 degrader-1 suppresses the growth of HER2-positive xenografts. PROTAC HER2 degrader-1 can be used in HER2-positive cancer-related research .
Cat. No.: HY-177009
CAS No.: 2897641-09-5
Research Areas:
Tucatinib analog B is a HER2 ligand and a derivative of Tucatinib (HY-16069). Tucatinib analog B can be used in the synthesis of PROTAC degraders, such as serving as the target protein ligand for PROTAC HER2 degrader-1 (HY-177008). Tucatinib analog B is applicable to studies related to HER2-positive cancers .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
