Tucatinib analog B
Tucatinib analog B is a HER2 ligand and a derivative of Tucatinib (HY-16069). Tucatinib analog B can be used in the synthesis of PROTAC degraders, such as serving as the target protein ligand for PROTAC HER2 degrader-1 (HY-177008). Tucatinib analog B is applicable to studies related to HER2-positive cancers.
For research use only. We do not sell to patients.
- CAS No.: 2897641-09-5
- Formula: C29H32N8O3
- Molecular Weight:540.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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HER2 |
Tucatinib analog B serves as the target protein ligand of PROTAC HER2 degrader-1 (HY-177008), a selective HER2 PROTAC degrader with a DC50 of 69 nM. PROTAC HER2 degrader-1 inhibits the proliferation of HER2-positive cells and tumor growth through sustained HER2 degradation and potent suppression of downstream pathways (AKT and ERK)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2897641-09-5
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Molecular Weight 540.62
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Formula C29H32N8O3
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SMILES
CC1=CC(NC2=C(C=C3OC)C(C=C3OCCCN4CCNCC4)=NC=N2)=CC=C1OC5=CC6=NC=NN6C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tucatinib analog B Related Classifications
HY-177009 Related Classifications
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