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Cat. No.: HY-177009

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Tucatinib analog B

Tucatinib analog B is a HER2 ligand and a derivative of Tucatinib (HY-16069). Tucatinib analog B can be used in the synthesis of PROTAC degraders, such as serving as the target protein ligand for PROTAC HER2 degrader-1 (HY-177008). Tucatinib analog B is applicable to studies related to HER2-positive cancers.

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CAS No.: 2897641-09-5
Formule: C₂₉H₃₂N₈O₃
Masse moléculaire:540.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Tucatinib analog B Chemical Structure

CAS No.: 2897641-09-5

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

HER2

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

Tucatinib analog B serves as the target protein ligand of PROTAC HER2 degrader-1 (HY-177008), a selective HER2 PROTAC degrader with a DC₅₀ of 69 nM. PROTAC HER2 degrader-1 inhibits the proliferation of HER2-positive cells and tumor growth through sustained HER2 degradation and potent suppression of downstream pathways (AKT and ERK)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2897641-09-5
Masse moléculaire 540.62
Formule C₂₉H₃₂N₈O₃
SMILES

CC1=CC(NC2=C(C=C3OC)C(C=C3OCCCN4CCNCC4)=NC=N2)=CC=C1OC5=CC6=NC=NN6C=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hu M, et al. Discovery of potent and selective HER2 PROTAC degrader based Tucatinib with improved efficacy against HER2 positive cancers. European journal of medicinal chemistry. 2022 Dec 15;244:114775. [Content Brief]

Calculators

Calculateur de molarité

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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