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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
PRT3789
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "PRT3789" in MCE Product Catalog:
Cat. No.: HY-159607
CAS No.: 2755761-78-3
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Research Areas:
PRT3789 is a selective SMARCA2 PROTAC degrader (DC50 in HeLa cell: 0.72 nM for SMARCA2, 14 nM for SMARCA4). PRT3789 forms a stable ternary complex with Von Hippel-Lindau (VHL) E3 ligase, induces polyubiquitination at SMARCA2-specific lysine residues, and drives proteasome-dependent SMARCA2 degradation. PRT3789 disrupts SWI/SNF chromatin remodeling complex integrity, induces dissociation of specific subunits, suppresses oncogenic gene expression, reduces chromatin accessibility, and upregulates antigen processing/presentation-related gene expression. PRT3789 induces synthetic lethality, inhibits proliferation and colony formation, and drives tumor growth inhibition and regression in SMARCA4-deficient contexts. PRT3789 can be used for the research of SMARCA4-mutated solid tumors, non-small cell lung cancer, endometrial cancer, colorectal cancer, bladder cancer, esophageal cancer, ovarian cancer, and gastric cancer .
Cat. No.: HY-159607A
CAS No.: 3023568-80-8
PRT3789 epimer is an epimer of PRT3789 (HY-159607). PRT3789 is a selective SMARCA2 PROTAC degrader .
Cat. No.: HY-159465A
CAS No.: 2725913-38-0
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(S)-E3 ligase Ligand 30 is an E3 ligand that can be used for the synthesis of PROTACs, such as PRT3789 epimer (HY-159607A) .
Cat. No.: HY-172738A
Research Areas:
(S)-E3 Ligase Ligand-linker Conjugate 175 is a conjugate of an E3 ligase ligand and linker, which can be used for the synthesis of PROTACs, such as PRT3789 epimer (HY-159607A) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
