2 Results for "

Pingyangmycin

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Pingyangmycin" in MCE Product Catalog:

1
Bleomycin A5
Bleomycin A5
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1 Cited Publications
Cat. No.: HY-N10470
CAS No.: 11116-32-8
Synonyms: Pingyangmycin
Category:  

Natural Products Microorganisms Animals

Target:  

Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy

Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe 2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .
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Bleomycin A5 hydrochloride
Bleomycin A5 hydrochloride
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Cat. No.: HY-125918
CAS No.: 55658-47-4
Synonyms: Pingyangmycin hydrochloride
Category:  

Microorganisms Antibiotics

Target:  

Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy

Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe 2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .
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