3 Results for "

Pomalidomide-2,6-diazaspiro[3.3]heptane

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Pomalidomide-2,6-diazaspiro[3.3]heptane" in MCE Product Catalog:

Cat. No.: HY-W1123955
CAS No.: 2226301-50-2
Target:  

Molecular Glues

Research Areas:  

Others

Pomalidomide-2,6-diazaspiro[3.3]heptane is a molecular glue.
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Cat. No.: HY-169232
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Cancer

PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 μM for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers .
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Cat. No.: HY-P1193
CAS No.: 129623-01-4
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .
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