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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
PqsA
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "PqsA" in MCE Product Catalog:
Category:
Cat. No.: HY-177852
CAS No.: 873556-29-7
Anthranilyl-AMSN is a potent PqsA inhibitor, with a Kiapp of 170 nM. Anthranilyl-AMSN decreases HHQ and PQS production. Anthranilyl-AMSN can be used in the research of Pseudomonas aeruginosa infections .
Cat. No.: HY-163481
CAS No.: 3033920-95-2
Antibiofilm agent-6 (Compound 26c) is a quorum sensing inhibitor with strong antibiofilm effects that can inhibit the fluorescence intensity of PAO1-lasB-gfp and PAO1-pqsA-gfp in a concentration-dependent manner. Antibiofilm agent-6 can inhibit the production of pyocyanin and rhamnolipid. Antibiofilm agent-6 aids helps ciprofloxacin (HY-B0356) effectively eliminate the living bacteria in a mouse model infected with P. aeruginosa PAO1 .
Cat. No.: HY-168948
CAS No.: 3063543-24-5
Quorum sensing-IN-9 (Compound 7d) inhibits quorum sensing in Pseudomonas aeruginosa by binding PqsR proteins. Quorum sensing-IN-9 inhibits the expression of quorum sensing systems related genes lasB, rhlA and pqsA, blocks the generation of virulence factors elastase, pyocyanin and rhamnolipid. Quorum sensing-IN-9 destorys the motility of P. aeruginosa, inhibits the biofilm formation, decreasing the virulence and pathogenicity of P. aeruginosa. Quorum sensing-IN-9 exhibits anti-infectious activity in Galleria mellonella larval model .
Cat. No.: HY-76705S
CAS No.: 2562378-12-3
Target:
Isotope-Labeled Compounds Bacterial DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Methyl N-methylanthranilate-d3 is the deuterated-labeled Methyl N-methylanthranilate (HY-76705). Methyl N-methylanthranilate is an N-alkylated anthranilate with a sweet citrus aroma, which is commonly used in perfume manufacturing. Methyl N-methylanthranilate is the dominant component in the defensive secretion of the millipede Typhloiulus orpheus. Methyl N-methylanthranilate exhibits quorum sensing inhibition and anti-biofilm activity against P. aeruginosa; it interferes with PQS synthesis via competitive inhibition of PqsA, but lacks bactericidal activity. Methyl N-methylanthranilate is sensitive to UVA/sunlight in human skin cells, and generates O2• - through type I photodynamic reactions, leading to lysosomal/mitochondrial damage, double-strand DNA breaks and apoptosis, with potential phototoxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
