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Protein regulator of cytokinesis 1

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By Targets:	Apoptosis (1) Caspase (1) Microtubule/Tubulin (1)
By Research Areas:	Cancer (1)

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Recombinant Proteins

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Targets Recommended: DOCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-179466

BKT300	Microtubule/Tubulin Apoptosis Caspase	Cancer
BKT300 is a potent and selective protein regulator of cytokinesis 1 (PRC1) inhibitor. BKT300 inhibits PRC1 dephosphorylation at T481, disrupts actin and microtubule formation, induces G2/M cell cycle arrest, triggers mitotic catastrophe, and promotes apoptosis, thereby inhibiting proliferation and migration of acute myeloid leukemia (AML) cells while sparing normal cells. BKT300 inhibits tumor growth in mouse xenograft AML models. BKT300 can be used for the research of AML .

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HY-P74620

	PRC1 Protein, Human (sf9, His) Protein regulator of cytokinesis 1; PRC1	Human	Sf9 insect cells
	PRC1 is a key regulator of cytokinesis, coordinating midzone formation and successful cell division by cross-linking microtubules and recruiting essential proteins such as KIF14, PLK1 and ECT2. Its effects extend to tumorigenesis, promoting bladder cancer cell proliferation and inhibiting apoptosis. PRC1 Protein, Human (sf9, His) is the recombinant human-derived PRC1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

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Host:	Rabbit (4)
Reactivity:	Human (4) Rat (2)
Application:	IHC-P (4) ICC/IF (2) IP (2) IHC-F (2) WB (4)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Phosphorylated (1) Unmodified (1)

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HY-P81971

	PRC1 Antibody (YA1716) Protein regulator of cytokinesis 1	WB, IHC-P, IP	Human, Rat
	PRC1 Antibody (YA1716) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRC1.

HY-P81971A

	PRC1 Antibody (YA1716)(PBS only) Protein regulator of cytokinesis 1	WB, IHC-P, IP	Human, Rat
	PRC1 Antibody (YA1716) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRC1.

HY-P81968

	Phospho-PRC1 (Thr481) Antibody (YA1713) Protein regulator of cytokinesis 1	WB, IHC-F, IHC-P, ICC/IF	Human
	Phospho-PRC1 (Thr481) Antibody (YA1713) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PRC1 (Thr481).

HY-P81968A

	Phospho-PRC1 (Thr481) Antibody (YA1713)(PBS only) Protein regulator of cytokinesis 1	WB, IHC-F, IHC-P, ICC/IF	Human
	Phospho-PRC1 (Thr481) Antibody (YA1713) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PRC1 (Thr481).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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